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Porcine cytomegalovirus/porcine roseolovirus (PCMV/PRV): A threat for xenotransplantation?
- Publication Year :
- 2022
- Publisher :
- Wiley-Blackwell Publishing, Inc., 2022.
-
Abstract
- The potential for a donor-derived transmission of porcine cytomegalovirus/porcine roseolovirus (PCMV/PRV) to the recipient has been recognized since pigs were considered candidate donors for xenotransplantation. This review gives a short description of the viral properties and summarizes the current evidence of the effects of PCMV/PRV transmission in preclinical xenotransplantation. Despite evidence that PCMV/PRV does not infect human and non-human primate cells, activation in the transplanted organ and detrimental systemic complications have been described. As PCMV/PRV is a herpesvirus able to establish latency, the importance of adequate screening of donor pigs is emphasized, as no efficient treatment is available. Furthermore, easy and successful ways of elimination of PCMV/PRV from pig herds are indicated.
- Subjects :
- Primates
2403 Immunology
Transplantation
porcine cytomegalovirus
Swine
PCR methods
2747 Transplantation
Transplantation, Heterologous
Immunology
Cytomegalovirus
610 Medicine & health
Tissue Donors
10234 Clinic for Infectious Diseases
herpes viruses
Western blot analysis
xenotransplantation
Cytomegalovirus Infections
Animals
Humans
porcine roseolovirus
Roseolovirus
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....e8adadc7cc40bfcec669558fe15097b8
- Full Text :
- https://doi.org/10.5167/uzh-225153