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Biological Study of a Nontoxic, Water-Soluble Immunoadjuvant from Mycobacterial Cell Walls
- Source :
- Proceedings of the National Academy of Sciences. 69:855-858
- Publication Year :
- 1972
- Publisher :
- Proceedings of the National Academy of Sciences, 1972.
-
Abstract
- Whole mycobacterial cells, which are used in Freund's complete adjuvant, besides inducing hypersensitivity to tuberculoprotein, also can elicit hyperreactivity to endotoxins, lymphoid hyperplasia, and allergic polyarthritis in rats. The data reported here demonstrate that a potent water-soluble adjuvant obtained from mycobacterial cell walls is also effective in increasing the immune response to viruses, and that it is free of the toxic effects observed with whole mycobacterial cells.
- Subjects :
- Male
Ovalbumin
medicine.medical_treatment
Freund's Adjuvant
Guinea Pigs
Orthomyxoviridae
Mice, Inbred Strains
Antigen-Antibody Complex
Tuberculin
Immunoadjuvant
Lymphoid hyperplasia
Mycobacterium
Microbiology
Cell wall
Mice
Immune system
Adjuvants, Immunologic
Cell Wall
medicine
Animals
Hypersensitivity, Delayed
Encephalomyocarditis virus
Multidisciplinary
biology
Arthritis
biology.organism_classification
Rats
Endotoxins
Precipitins
Freund's adjuvant
Antibody Formation
Splenomegaly
Immunology
biology.protein
medicine.symptom
Biological Sciences: Immunology
Adjuvant
Hepatomegaly
Subjects
Details
- ISSN :
- 10916490 and 00278424
- Volume :
- 69
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences
- Accession number :
- edsair.doi.dedup.....e8a6494e67e416eed7cf541b137a26c5