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Differential requirement for STAT by gain-of-function and wild-type receptor tyrosine kinase Torso in Drosophila
- Source :
- Development (Cambridge, England), Development (Cambridge, England), Company of Biologists, 2002, 129 (8), pp.4241-4248
- Publication Year :
- 2002
- Publisher :
- HAL CCSD, 2002.
-
Abstract
- Malignant transformation frequently involves aberrant signaling from receptor tyrosine kinases (RTKs). These receptors commonly activate Ras/Raf/MEK/MAPK signaling but when overactivated can also induce the JAK/STAT pathway, originally identified as the signaling cascade downstream of cytokine receptors. Inappropriate activation of STAT has been found in many human cancers. However, the contribution of the JAK/STAT pathway in RTK signaling remains unclear. We have investigated the requirement of the JAK/STAT pathway for signaling by wild-type and mutant forms of the RTK Torso (Tor) using a genetic approach in Drosophila. Our results indicate that the JAK/STAT pathway plays little or no role in signaling by wild-type Tor. In contrast, we find that STAT, encoded by marelle (mrl; DStat92E), is essential for the gain-of-function mutant Tor (TorGOF) to activate ectopic gene expression. Our findings indicate that the Ras/Raf/MEK/MAPK signaling pathway is sufficient to mediate the normal functions of wild-type RTK, whereas the effects of gain-of-function mutant RTK additionally require STAT activation.
- Subjects :
- Embryo, Nonmammalian
MAP Kinase Signaling System
[SDV]Life Sciences [q-bio]
Receptor Protein-Tyrosine Kinases
Polymerase Chain Reaction
Article
stat
Receptor tyrosine kinase
Consensus Sequence
Animals
Drosophila Proteins
Protein inhibitor of activated STAT
SOCS3
Molecular Biology
STAT4
STAT6
gène torso
Base Sequence
biology
fungi
Gene Expression Regulation, Developmental
JAK-STAT signaling pathway
Molecular biology
Cell biology
DNA-Binding Proteins
STAT Transcription Factors
INSECTE
Drosophila melanogaster
Mutation
Trans-Activators
biology.protein
Plasmids
Developmental Biology
Subjects
Details
- Language :
- English
- ISSN :
- 14779129
- Database :
- OpenAIRE
- Journal :
- Development (Cambridge, England), Development (Cambridge, England), Company of Biologists, 2002, 129 (8), pp.4241-4248
- Accession number :
- edsair.doi.dedup.....e89d6c5f37174f5871ad60fb23aa767b