Back to Search
Start Over
Acute myocardial infarction associated with high dose intravenous immunoglobulin infusion for autoimmune disorders. A study of four cases
- Source :
- Annals of the rheumatic diseases. 59(1)
- Publication Year :
- 2000
-
Abstract
- OBJECTIVE To report on four patients with autoimmune disorders who developed acute myocardial infarction (MI) during or soon after treatment with high dose intravenous immunoglobulins (IVIG) and to determine the clinical profile of patients prone to this complication. METHODS The clinical history of the four patients is reported with details concerning age, sex, indication for IVIG treatment, risk factors, timing of the MI and outcome. The relevant medical literature has been reviewed. RESULTS The patients, three men and one woman, aged 42–67, received IVIG treatment for different autoimmune disorders. All had a history of atherosclerosis or previous risk factors such as hypertension, stroke, hyperlipidaemia and obesity. Two of the patients suffered a MI after the first infusion of IVIG while the others—after the 5th and 15th pulses. MI occurred during the infusion in two patients and after a few days in the others. All the patients recovered from the acute event. These observations are in concert with sporadic cases of IVIG related thrombosis reported in the medical literature. CONCLUSION In patients with vascular risk factors such as old age, hypertension, history of stroke or coronary artery disease, the possibility of IVIG related vascular complications should be considered and IVIG prescribed with a cautious reweighted risk/benefit consideration.
- Subjects :
- Adult
Male
medicine.medical_specialty
Concise Report
medicine.medical_treatment
Immunology
Myocardial Infarction
General Biochemistry, Genetics and Molecular Biology
Autoimmune Diseases
Coronary artery disease
Rheumatology
Risk Factors
Internal medicine
hemic and lymphatic diseases
Immunology and Allergy
Medicine
Humans
Myocardial infarction
Stroke
Aged
Autoimmune disease
Chemotherapy
business.industry
Immunoglobulins, Intravenous
Middle Aged
medicine.disease
Thrombosis
Surgery
Female
business
Complication
Medical literature
Subjects
Details
- ISSN :
- 00034967
- Volume :
- 59
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Annals of the rheumatic diseases
- Accession number :
- edsair.doi.dedup.....e88f1457a6a8838207788727a6b12da4