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Vagal Hyperactivity Due to Ventromedial Hypothalamic Lesions Increases Adiponectin Production and Release
- Source :
- Diabetes. 63:1637-1648
- Publication Year :
- 2014
- Publisher :
- American Diabetes Association, 2014.
-
Abstract
- In obese humans and animals, adiponectin production and release in adipose tissue are downregulated by feedback inhibition, resulting in decreased serum adiponectin. We investigated adiponectin production and release in ventromedial hypothalamic (VMH)-lesioned animals. VMH-lesioned mice showed significant increases in food intake and body weight gain, with hyperinsulinemia and hyperleptinemia at 1 and 4 weeks after VMH-lesioning. Serum adiponectin was elevated in VMH-lesioned mice at 1 and 4 weeks, despite adipocyte hypertrophy in subcutaneous and visceral adipose tissues and increased body fat. Adiponectin production and mRNA were also increased in both adipose tissues in VMH-lesioned mice at 1 week. These results were replicated in VMH-lesioned rats at 1 week. Daily atropine administration for 5 days or subdiaphragmatic vagotomy completely reversed the body weight gain and eliminated the increased adiponectin production and release in these rats, with reversal to a normal serum adiponectin level. Parasympathetic nerve activation by carbachol infusion for 5 days in rats increased serum adiponectin, with increased adiponectin production in visceral and subcutaneous adipose tissues without changes of body weight. These results demonstrate that activation of the parasympathetic nerve by VMH lesions stimulates production of adiponectin in visceral and subcutaneous adipose tissues and adiponectin release, resulting in elevated serum adiponectin.
- Subjects :
- Atropine
Blood Glucose
Leptin
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Adipose tissue
Rats, Sprague-Dawley
Mice
Parasympathetic nervous system
Parasympathetic Nervous System
Internal medicine
Internal Medicine
medicine
Hyperinsulinemia
Animals
Insulin
Oxidopamine
Adiponectin
business.industry
nutritional and metabolic diseases
Vagus Nerve
medicine.disease
Rats
Vagus nerve
medicine.anatomical_structure
Endocrinology
Adipose Tissue
Ventromedial Hypothalamic Nucleus
Carbachol
Female
Adipocyte hypertrophy
business
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 1939327X and 00121797
- Volume :
- 63
- Database :
- OpenAIRE
- Journal :
- Diabetes
- Accession number :
- edsair.doi.dedup.....e881b1170a50ee9c8c008bc3fc388665