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Re-examining ferritin-bound iron: current and developing clinical tools

Authors :
David Simpson
Liam T. Hall
Gawain McColl
Erin S Grant
Danielle Clucas
Source :
Clinical Chemistry and Laboratory Medicine (CCLM). 59:459-471
Publication Year :
2020
Publisher :
Walter de Gruyter GmbH, 2020.

Abstract

Iron is a highly important metal ion cofactor within the human body, necessary for haemoglobin synthesis, and required by a wide range of enzymes for essential metabolic processes. Iron deficiency and overload both pose significant health concerns and are relatively common world-wide health hazards. Effective measurement of total iron stores is a primary tool for both identifying abnormal iron levels and tracking changes in clinical settings. Population based data is also essential for tracking nutritional trends. This review article provides an overview of the strengths and limitations associated with current techniques for diagnosing iron status, which sets a basis to discuss the potential of a new serum marker – ferritin-bound iron – and the improvement it could offer to iron assessment.

Details

ISSN :
14374331 and 14346621
Volume :
59
Database :
OpenAIRE
Journal :
Clinical Chemistry and Laboratory Medicine (CCLM)
Accession number :
edsair.doi.dedup.....e87d9e64d37144feb82c44bd7b5adcd9
Full Text :
https://doi.org/10.1515/cclm-2020-1095