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2,6,9-trisubstituted purines : Optimization towards highly potent and selective CDK1 inhibitors
- Source :
- Bioorganic & Medicinal Chemistry Letters. 9:91-96
- Publication Year :
- 1999
- Publisher :
- Elsevier BV, 1999.
-
Abstract
- Novel 2,6,9-substituted purine derivatives represent a class of potent and selective inhibitors of CDK1/cyclinB. The synthesis, SAR and biological profile of selected compounds are described.
- Subjects :
- Protein Kinase C-alpha
Stereochemistry
Clinical Biochemistry
Pharmaceutical Science
Antineoplastic Agents
Biochemistry
Chemical synthesis
Structure-Activity Relationship
CDC2 Protein Kinase
Drug Discovery
Humans
Structure–activity relationship
Enzyme Inhibitors
Purine metabolism
Molecular Biology
Protein Kinase C
chemistry.chemical_classification
Cyclin-dependent kinase 1
Epidermal Growth Factor
biology
Chemistry
Organic Chemistry
Kinetin
Cyclic AMP-Dependent Protein Kinases
In vitro
Isoenzymes
Enzyme
Purines
Enzyme inhibitor
biology.protein
Molecular Medicine
Purine derivative
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....e8638b648cb46fdd6c73ca249c80316e
- Full Text :
- https://doi.org/10.1016/s0960-894x(98)00691-x