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Potential of Early [ 18 F]-2-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography for Identifying Hypoperfusion and Predicting Fate of Tissue in a Rat Embolic Stroke Model
- Source :
- Stroke. 43:193-198
- Publication Year :
- 2012
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2012.
-
Abstract
- Background and Purpose— Experimental stroke models are essential to study in vivo pathophysiological processes of focal cerebral ischemia. In this study, an embolic stroke model in rats was applied (1) to characterize early development of regional cerebral blood flow and metabolism with positron emission tomography (PET) using [ 15 O]H 2 O and [ 18 F]-2-fluoro-2-deoxy-D-glucose (FDG); and (2) to identify potential parameters for predicting tissue fate. Methods— Remote occlusion of the middle cerebral artery was induced in 10 Wistar rats by injection of 4 TiO 2 macrospheres. Sequential [ 15 O]H 2 O-PET (baseline, 5, 30, 60 minutes after middle cerebral artery occlusion) and FDG-PET measurements (75 minutes after middle cerebral artery occlusion) were performed. [ 15 O]H 2 O-PET data and FDG kinetic parameters were compared with MRIs and histology at 24 hours. Results— Regional cerebral blood flow decreased substantially within 30 minutes after middle cerebral artery occlusion (41% to 58% of baseline regional cerebral blood flow; P K1 of FDG in all animals ( r =0.86±0.09; P K1 and net influx rate constant Ki of FDG. The infarct volume predicted by FDG-PET (375.8±102.3 mm 3 ) correlated significantly with the infarct size determined by MRI after 24 hours (360.8±93.7 mm 3 ; r =0.85). Conclusions— Hypoperfused tissue can be identified by decreased K1 of FDG. Acute ischemic tissue can be well characterized using K1 and Ki allowing for discrimination between infarct core and early viable tissue. Because FDG-PET is widely spread, our findings can be easily translated into clinical application for early diagnoses of ischemia.
- Subjects :
- medicine.medical_specialty
Ischemia
Brain Ischemia
Fluorodeoxyglucose F18
Internal medicine
medicine.artery
Occlusion
medicine
Animals
Rats, Wistar
Stroke
Advanced and Specialized Nursing
medicine.diagnostic_test
business.industry
Penumbra
Brain
Infarction, Middle Cerebral Artery
medicine.disease
Rats
Disease Models, Animal
Cerebral blood flow
Positron emission tomography
Cerebrovascular Circulation
Positron-Emission Tomography
Middle cerebral artery
Cardiology
Neurology (clinical)
Radiology
Cardiology and Cardiovascular Medicine
business
Perfusion
Subjects
Details
- ISSN :
- 15244628 and 00392499
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Stroke
- Accession number :
- edsair.doi.dedup.....e85553aaac3bb81587d30bb638ff3932