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Adverse events of monoclonal antibodies used for cancer therapy
- Source :
- BioMed Research International, BioMed Research International, Vol 2015 (2015)
- Publication Year :
- 2014
-
Abstract
- In 1997, the first monoclonal antibody (MoAb), the chimeric anti-CD20 molecule rituximab, was approved by the US Food and Drug administration for use in cancer patients. Since then, the panel of MoAbs that are approved by international regulatory agencies for the treatment of hematopoietic and solid malignancies has continued to expand, currently encompassing a stunning amount of 20 distinct molecules for 11 targets. We provide a brief scientific background on the use of MoAbs in cancer therapy, review all types of monoclonal antibodies-related adverse events (e.g., allergy, immune-related adverse events, cardiovascular adverse events, and pulmonary adverse events), and discuss the mechanism and treatment of adverse events.
- Subjects :
- Allergy
medicine.drug_class
Antibodies, Neoplasm
Cancer therapy
lcsh:Medicine
Review Article
Monoclonal antibody
General Biochemistry, Genetics and Molecular Biology
Neoplasms
medicine
Humans
Adverse effect
General Immunology and Microbiology
biology
business.industry
lcsh:R
Cancer
General Medicine
medicine.disease
Monoclonal
Immunology
biology.protein
Rituximab
Antibody
business
medicine.drug
Subjects
Details
- ISSN :
- 23146141
- Volume :
- 2015
- Database :
- OpenAIRE
- Journal :
- BioMed research international
- Accession number :
- edsair.doi.dedup.....e85442868efde2f1e8c4fb3832bcec28