Back to Search
Start Over
Synthesis of Structurally Defined Cationic Polythiophenes for DNA Binding and Gene Delivery
- Source :
- ACS applied materialsinterfaces. 10(5)
- Publication Year :
- 2018
-
Abstract
- Water-soluble conjugated polymers (WCPs) have prospective applications in the field of bioimaging, disease diagnosis, and therapy. However, the use of WCPs with controllability and regioregularity for bioapplications have scarcely been reported. In this work, we synthesized polythiophenes containing ester side chains (P3ET) via Kumada catalyst-transfer polycondensation (KCTP) and confirmed a quasi-“living” chain-growth mechanism. In addition, we obtained cationic regioregular polythiophenes (cPTs) by aminolysis of P3ET with varied chain lengths, and studied DNA binding capability and gene delivery performance. Benefiting from photocontrolled generation of intracellular reactive oxygen species (ROS), the cationic polythiophenes successfully delivered DNA into tumor cells without additional polymer species.
- Subjects :
- chemistry.chemical_classification
Condensation polymer
Materials science
Polymers
Cationic polymerization
02 engineering and technology
Polymer
DNA
Thiophenes
Gene delivery
Conjugated system
010402 general chemistry
021001 nanoscience & nanotechnology
01 natural sciences
Combinatorial chemistry
0104 chemical sciences
chemistry.chemical_compound
Aminolysis
chemistry
Cations
Side chain
General Materials Science
Prospective Studies
0210 nano-technology
Subjects
Details
- ISSN :
- 19448252
- Volume :
- 10
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- ACS applied materialsinterfaces
- Accession number :
- edsair.doi.dedup.....e84d1785ee048c7160f25eacad6d1a9c