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Identification of a prognostic signature based on immune-related genes in bladder cancer
- Source :
- Genomics. 113:1203-1218
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Bladder cancer (BLCA) has a high incidence and recurrence rate, and the effect of immunotherapy varies from person to person. Immune-related genes (IRGs) have been shown to be associated with immunotherapy and prognosis in many other cancers, but their role in immunogenic BLCA is less well defined. In this study, we constructed an eight-IRG risk model, which demonstrated strong prognostic and immunotherapeutic predictive power. The signature was significantly related to tumor clinicopathological characteristics, tumor class, immune cell infiltration and mutation status. Additionally, a nomogram containing the risk score and other potential risk factors could effectively predict the long-term overall survival probability of BLCA patients. The enriched mechanisms identified by gene set enrichment analysis suggested that the reason why this signature can accurately distinguish high- and low-risk populations may be closely related to the different degrees of innate immune response and T cell activation in different patients.
- Subjects :
- 0106 biological sciences
Oncology
medicine.medical_specialty
medicine.medical_treatment
T cell
Biology
medicine.disease_cause
01 natural sciences
03 medical and health sciences
Internal medicine
Biomarkers, Tumor
Genetics
medicine
Humans
IRGs
030304 developmental biology
0303 health sciences
Mutation
Innate immune system
Framingham Risk Score
Bladder cancer
Immunotherapy
Nomogram
Prognosis
medicine.disease
Gene Expression Regulation, Neoplastic
Nomograms
medicine.anatomical_structure
Urinary Bladder Neoplasms
010606 plant biology & botany
Subjects
Details
- ISSN :
- 08887543
- Volume :
- 113
- Database :
- OpenAIRE
- Journal :
- Genomics
- Accession number :
- edsair.doi.dedup.....e83cc549a7b92c91625448cb1b6d10af