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Peak Activation Shifts in the Sensorimotor Cortex of Chronic Stroke Patients Following Robot-assisted Rehabilitation Therapy
- Source :
- The open neuroimaging journal
- Publication Year :
- 2021
- Publisher :
- Bentham Science Publishers Ltd., 2021.
-
Abstract
- Background: Ischemic stroke is the most common cause of complex chronic disability and the third leading cause of death worldwide. In recovering stroke patients, peak activation within the ipsilesional primary motor cortex (M1) during the performance of a simple motor task has been shown to exhibit an anterior shift in many studies and a posterior shift in other studies. Objective: We investigated this discrepancy in chronic stroke patients who completed a robot-assisted rehabilitation therapy program. Methods: Eight chronic stroke patients with an intact M1 and 13 Healthy Control (HC) volunteers underwent 300 functional magnetic resonance imaging (fMRI) scans while performing a grip task at different force levels with a robotic device. The patients were trained with the same robotic device over a 10-week intervention period and their progress was evaluated serially with the Fugl-Meyer and Modified Ashworth scales. Repeated measure analyses were used to assess group differences in locations of peak activity in the sensorimotor cortex (SM) and the relationship of such changes with scores on the Fugl-Meyer Upper Extremity (FM UE) scale. Results: Patients moving their stroke-affected hand had proportionally more peak activations in the primary motor area and fewer peak activations in the somatosensory cortex than the healthy controls (P=0.009). They also showed an anterior shift of peak activity on average of 5.3-mm (P Conclusion: A stroke rehabilitation grip task with a robotic device was confirmed to be feasible during fMRI scanning and thus amenable to be used to assess plastic changes in neurological motor activity. Location of peak activity in the SM is a promising clinical neuroimaging index for the evaluation and monitoring of chronic stroke patients.
- Subjects :
- medicine.medical_specialty
medicine.medical_treatment
Functional magnetic resonance imaging
MR compatible robotic devices
030204 cardiovascular system & hematology
Somatosensory system
Article
03 medical and health sciences
0302 clinical medicine
Physical medicine and rehabilitation
Neuroimaging
Neuroplasticity
Medicine
Radiology, Nuclear Medicine and imaging
Stroke
Brain plasticity
Hand rehabilitation
Rehabilitation
medicine.diagnostic_test
business.industry
Fugl-meyer upper extremity scale
Repeated measures design
medicine.disease
Neurology (clinical)
Primary motor cortex
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 18744400
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- The Open Neuroimaging Journal
- Accession number :
- edsair.doi.dedup.....e836db3c4e71c0dfd73669f468e7ba52
- Full Text :
- https://doi.org/10.2174/1874440002114010008