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Pyridine Scaffolds, Phenols and Derivatives of Azo Moiety: Current Therapeutic Perspectives
- Source :
- Molecules, Molecules, Vol 26, Iss 4872, p 4872 (2021)
- Publication Year :
- 2021
-
Abstract
- Synthetic heterocyclic compounds have incredible potential against different diseases; pyridines, phenolic compounds and the derivatives of azo moiety have shown excellent antimicrobial, antiviral, antidiabetic, anti-melanogenic, anti-ulcer, anticancer, anti-mycobacterial, anti-inflammatory, DNA binding and chemosensing activities. In the present review, the above-mentioned activities of the nitrogen-containing heterocyclic compounds (pyridines), hydroxyl (phenols) and azo derivatives are discussed with reference to the minimum inhibitory concentration and structure–activity relationship, which clearly indicate that the presence of nitrogen in the phenyl ring; in addition, the hydroxyl substituent and the incorporation of a diazo group is crucial for the improved efficacies of the compounds in probing different diseases. The comparison was made with the reported drugs and new synthetic derivatives that showed recent therapeutic perspectives made in the last five years.
- Subjects :
- pyridine
Pyridines
Substituent
Pharmaceutical Science
Organic chemistry
azo
Review
heterocyclic
Analytical Chemistry
chemistry.chemical_compound
Minimum inhibitory concentration
QD241-441
Imaging, Three-Dimensional
Phenols
Drug Discovery
Pyridine
Moiety
Phenol
phenol
Physical and Theoretical Chemistry
Antimicrobial
Combinatorial chemistry
therapeutic
chemistry
Chemistry (miscellaneous)
Molecular Medicine
hydroxyl
Diazo
Azo Compounds
Subjects
Details
- ISSN :
- 14203049
- Volume :
- 26
- Issue :
- 16
- Database :
- OpenAIRE
- Journal :
- Molecules (Basel, Switzerland)
- Accession number :
- edsair.doi.dedup.....e82885a10911446c7fa9cd371673af59