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Roles of Nitric Oxide and Prostaglandins in the Sustained Antihypertensive Effects of Acanthospermum hispidum DC. on Ovariectomized Rats with Renovascular Hypertension
- Source :
- Evidence-Based Complementary and Alternative Medicine, Vol 2017 (2017), Evidence-based Complementary and Alternative Medicine : eCAM
- Publication Year :
- 2017
- Publisher :
- Hindawi Limited, 2017.
-
Abstract
- Although Acanthospermum hispidum is used in Brazilian folk medicine as an antihypertensive, no study evaluated its effects on a renovascular hypertension and ovariectomy model. So, this study investigated the mechanisms involved in the antihypertensive effects of an ethanol-soluble fraction obtained from A. hispidum (ESAH) using two-kidney-one-clip hypertension in ovariectomized rats (2K1C plus OVT). ESAH was orally administered at doses of 30, 100, and 300 mg/kg, daily, for 28 days, after 5 weeks of surgery. Enalapril (15 mg/kg) and hydrochlorothiazide (25 mg/kg) were used as standard drugs. Diuretic activity was evaluated on days 1, 7, 14, 21, and 28. Systolic, diastolic, and mean blood pressure and heart rate were recorded. Serum creatinine, urea, thiobarbituric acid reactive substances, nitrosamine, nitrite, aldosterone, vasopressin levels, and ACE activity were measured. The vascular reactivity and the role of nitric oxide (NO) and prostaglandins (PG) in the vasodilator response of ESAH on the mesenteric vascular bed (MVB) were also investigated. ESAH treatment induced an important saluretic and antihypertensive response, therefore recovering vascular reactivity in 2K1C plus OVT-rats. This effect was associated with a reduction of oxidative and nitrosative stress with a possible increase in the NO bioavailability. Additionally, a NO and PG-dependent vasodilator effect was observed on the MEV.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Vasopressin
Article Subject
030204 cardiovascular system & hematology
Pharmacology
Renovascular hypertension
Nitric oxide
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Hydrochlorothiazide
Internal medicine
medicine
Enalapril
Aldosterone
biology
business.industry
lcsh:Other systems of medicine
lcsh:RZ201-999
biology.organism_classification
medicine.disease
030104 developmental biology
Endocrinology
Complementary and alternative medicine
chemistry
Acanthospermum hispidum
Ovariectomized rat
business
Research Article
medicine.drug
Subjects
Details
- ISSN :
- 17414288 and 1741427X
- Volume :
- 2017
- Database :
- OpenAIRE
- Journal :
- Evidence-Based Complementary and Alternative Medicine
- Accession number :
- edsair.doi.dedup.....e82238446a7b86284df250bef9a1f518