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The effects of augmentation cystoplasty and botulinum toxin injection on patient-reported bladder function and quality of life among individuals with spinal cord injury performing clean intermittent catheterization
- Source :
- Neurourology and urodynamics. 38(1)
- Publication Year :
- 2018
-
Abstract
- AIMS Clean intermittent catheterization (CIC) is recommended after spinal cord injury (SCI) because it has the least complications, however, CIC has a high discontinuation rate. We hypothesized that bladder botulinum toxin injection or augmentation cystoplasty may improve satisfaction with CIC. METHODS The NBRG registry is a multicenter, prospective, observational study asking SCI participants about neurogenic bladder (NGB) related quality of life (QoL). In this study, participants performing CIC as primary bladder management were categorized into 3 groups: (1) CIC alone (CIC); (2) CIC with botulinum toxin (CIC-BTX); and (3) CIC with augmentation cystoplasty (CIC-AUG). Outcomes included primary: Neurogenic Bladder Symptom Score (NBSS) and SCI-QoL Bladder Management Difficulties, and secondary: NBSS subdomains (Incontinence, Storage & Voiding, Consequences) and the NBSS final question (satisfaction with urinary function). Multivariable regression, controlling for multiple factors was used to establish differences between the three groups. RESULTS Eight hundred seventy-nine participants performed CIC as primary bladder management and had the following characteristics: mean age 43.4 (±12.9) and years from injury 13.7 (±10.7), tetraplegia in 284 (32%), and 543 (62%) were men. Bladder management was CIC in 593 (67%), CIC-BTX in 161 (19%), and CIC-AUG in 125(15%). Primary outcomes: CIC-AUG had associated improved total NBSS versus CIC(-3.2(-5.2 to -1.2), P = 0.001 and CIC-BTX(-3.9(-6.3 to -1.6), P = 0.001), CIC-AUG also had better SCI-QoL Difficulties scores versus CIC(-4(-5.48 to -2.53, P
- Subjects :
- Adult
Male
medicine.medical_specialty
Urology
030232 urology & nephrology
Urination
03 medical and health sciences
0302 clinical medicine
Quality of life
medicine
Humans
Intermittent Urethral Catheterization
Patient Reported Outcome Measures
Prospective Studies
Botulinum Toxins, Type A
Urinary Bladder, Neurogenic
Augmentation cystoplasty
Spinal cord injury
Tetraplegia
Spinal Cord Injuries
030219 obstetrics & reproductive medicine
business.industry
Clean Intermittent Catheterization
Middle Aged
medicine.disease
Urinary function
Botulinum toxin
Discontinuation
Quality of Life
Female
Neurology (clinical)
business
medicine.drug
Subjects
Details
- ISSN :
- 15206777
- Volume :
- 38
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Neurourology and urodynamics
- Accession number :
- edsair.doi.dedup.....e81ac82d755bb1aaddceaf9ad14ffa65