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Magnetoencephalographic Abnormalities in Creutzfeldt-Jakob Disease: A Case Report
- Source :
- Case Reports in Neurology, Vol 2, Iss 3, Pp 122-127 (2010), Case Reports in Neurology
- Publication Year :
- 2010
- Publisher :
- S. Karger AG, 2010.
-
Abstract
- Creutzfeldt-Jakob disease (CJD) is a rare neurodegenerative disease with no effective therapy available. We recorded spontaneous magnetoencephalography and auditory evoked fields (AEFs) from a male patient with a rapidly progressive memory disorder, ataxia and myoclonus. Post-mortem examination confirmed sporadic CJD. Sources of the abnormal slow wave activity were localized with a beamformer software. Sources of sharp transients and AEFs were modeled with equivalent current dipoles. The estimated sources of spontaneous activity abnormalities were more dominant in the left hemisphere, in line with left-dominant abnormalities in diffusion-weighted MRI. Sources of AEFs were found in both temporal lobes. Magnetoencephalography measurements on CJD patients are feasible, and provide efficient means for localizing abnormal cortical activity in CJD.
- Subjects :
- Published: October 2010
Pathology
medicine.medical_specialty
Ataxia
Prion disease
Disease
lcsh:RC346-429
Lateralization of brain function
mental disorders
medicine
Memory disorder
lcsh:Neurology. Diseases of the nervous system
Transmissible spongiform encephalopathy
Sporadic CJD
medicine.diagnostic_test
business.industry
Magnetoencephalography
medicine.disease
Creutzfeldt-Jakob disease
nervous system diseases
Male patient
Neurology (clinical)
medicine.symptom
business
Myoclonus
Subjects
Details
- ISSN :
- 1662680X
- Volume :
- 2
- Database :
- OpenAIRE
- Journal :
- Case Reports in Neurology
- Accession number :
- edsair.doi.dedup.....e815fecf3307f1b4875d10a78013c2a3