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Ripple-selective GABAergic projection cells in the hippocampus

Ripple-selective GABAergic projection cells in the hippocampus

Authors :
Gergely G. Szabo
Jordan S. Farrell
Barna Dudok
Wen-Hsien Hou
Anna L. Ortiz
Csaba Varga
Prannath Moolchand
Cafer Ikbal Gulsever
Tilo Gschwind
Jordane Dimidschstein
Marco Capogna
Ivan Soltesz
Source :
Neuron, Szabo, G G, Farrell, J S, Dudok, B, Hou, W H, Ortiz, A L, Varga, C, Moolchand, P, Gulsever, C I, Gschwind, T, Dimidschstein, J, Capogna, M & Soltesz, I 2022, ' Ripple-selective GABAergic projection cells in the hippocampus ', Neuron, vol. 110, no. 12, pp. 1959-1977.e9 . https://doi.org/10.1016/j.neuron.2022.04.002
Publication Year :
2022
Publisher :
Elsevier BV, 2022.

Abstract

Ripples are brief high-frequency electrographic events with important roles in episodic memory. However, the in vivo circuit mechanisms coordinating ripple-related activity among local and distant neuronal ensembles are not well understood. Here, we define key characteristics of a long-distance projecting GABAergic cell group in the mouse hippocampus that selectively exhibits high-frequency firing during ripples while staying largely silent during theta-associated states when most other GABAergic cells are active. The high ripple-associated firing commenced before ripple onset and reached its maximum before ripple peak, with the signature theta-OFF, ripple-ON firing pattern being preserved across awake and sleep states. Controlled by septal GABAergic, cholinergic, and CA3 glutamatergic inputs, these ripple-selective cells innervate parvalbumin and cholecystokinin-expressing local interneurons while also targeting a variety of extra-hippocampal regions. These results demonstrate the existence of a hippocampal GABAergic circuit element that is uniquely positioned to coordinate ripple-related neuronal dynamics across neuronal assemblies.

Details

ISSN :
08966273
Volume :
110
Database :
OpenAIRE
Journal :
Neuron
Accession number :
edsair.doi.dedup.....e8126551717d0a88f1f7722737fb5adf
Full Text :
https://doi.org/10.1016/j.neuron.2022.04.002