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Photosensitivity of Different Nanodiamond–PMO Nanoparticles in Two-Photon-Excited Photodynamic Therapy
- Source :
- Life, Life, 2022, This article belongs to the Special Issue Photodynamic Diagnosis and Therapy, 12 (12), pp.2044. ⟨10.3390/life12122044⟩, Life, 2022, 12 (12), pp.2044. ⟨10.3390/life12122044⟩, Life; Volume 12; Issue 12; Pages: 2044
- Publication Year :
- 2022
- Publisher :
- MDPI AG, 2022.
-
Abstract
- Background: In addition to their great optical properties, nanodiamonds (NDs) have recently proved useful for two-photon-excited photodynamic therapy (TPE-PDT) applications. Indeed, they are able to produce reactive oxygen species (ROS) directly upon two-photon excitation but not with one-photon excitation; Methods: Fluorescent NDs (FNDs) with a 100 nm diameter and detonation NDs (DNDs) of 30 nm were compared. In order to use the gems for cancer-cell theranostics, they were encapsulated in a bis(triethoxysilyl)ethylene-based (ENE) periodic mesoporous organosilica (PMO) shell, and the surface of the formed nanoparticles (NPs) was modified by the direct grafting of polyethylene glycol (PEG) and amino groups using PEG-hexyltriethoxysilane and aminoundecyltriethoxysilane during the sol–gel process. The NPs’ phototoxicity and interaction with MDA-MB-231 breast cancer cells were evaluated afterwards; Results: Transmission electronic microscopy images showed the formation of core–shell NPs. Infrared spectra and zeta-potential measurements confirmed the grafting of PEG and NH2 groups. The encapsulation of the NDs allowed for the imaging of cancer cells with NDs and for the performance of TPE-PDT of MDA-MB-231 cancer cells with significant mortality. Conclusions: Multifunctional ND@PMO core–shell nanosystems were successfully prepared. The NPs demonstrated high biocompatibility and TPE-PDT efficiency in vitro in the cancer cell model. Such systems hold good potential for two-photon-excited PDT applications.
- Subjects :
- K. Ali
R. Bettache
theranostics
J.-O. Nguyen
Hadj-Kaddour
Gary-Bobo
K
J.-O
[SDV.CAN]Life Sciences [q-bio]/Cancer
L.M.A
Bondon
Raehm
General Biochemistry, Genetics and Molecular Biology
M
[SPI]Engineering Sciences [physics]
C
et al nanodiamond
Boukherroub
N. Durand
nanodiamond
two-photon excitation
mesoporous organosilica
cancer cells
Durand
L. Durand
Bettache
Ecology, Evolution, Behavior and Systematics
R
D. Hadj-Kaddour
Paleontology
L.M.A. Boukherroub
[CHIM.MATE]Chemical Sciences/Material chemistry
N
L
N. Gary-Bobo
Ali
M. Raehm
Space and Planetary Science
C. et al nanodiamond two-photon excitation mesoporous organosilica theranostics cancer cells
D
[SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic
Nguyen
Subjects
Details
- ISSN :
- 20751729
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Life
- Accession number :
- edsair.doi.dedup.....e8085bb10b02192430c4616fd769f9af