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Effects of laser irradiation on arthritic histopathology and heat shock protein 70 expression in C57 black mice with osteoarthritis
- Source :
- Journal of Chinese Integrative Medicine. 9:761-767
- Publication Year :
- 2011
- Publisher :
- Journal of Chinese Integrative Medicine Press, 2011.
-
Abstract
- OBJECTIVE To study the effects of three different laser treatments (650 nm alone, 10.6 μm alone and combined laser of 650 nm and 10.6 μm) on experimental osteoarthritis of the knees in C57 black mice. METHODS Sixty C57 black mice were divided randomly into 6 groups. Ten mice were assigned to a normal control group (no intervention) and the other 5 groups were subjected to a forced running regimen to induce osteoarthritis. One group was set as the model control group. The other 4 groups were given 90 s of a 650 nm laser, 90 s of a 10.6 μm laser, 90 s of a combined laser, or a sham treatment on acupoint Dubi (ST35) of the rear left leg 3 times per week for 4 weeks. The modified Mankin score was used to evaluate the degree of cartilage degradation. Immunohistochemical staining for heat shock protein (HSP) 70 was conducted. RESULTS Mankin scores of the model control group and the sham control group were significantly higher than that of the normal control group (P
- Subjects :
- Cartilage, Articular
Male
medicine.medical_specialty
Pathology
Acupuncture Therapy
Urology
Osteoarthritis
law.invention
Mice
law
Heat shock protein
medicine
Animals
HSP70 Heat-Shock Proteins
Irradiation
business.industry
Laser treatment
Cartilage
Osteoarthritis, Knee
medicine.disease
Laser
Hsp70
Mice, Inbred C57BL
medicine.anatomical_structure
Complementary and alternative medicine
Female
Histopathology
Laser Therapy
business
Subjects
Details
- ISSN :
- 16721977
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Journal of Chinese Integrative Medicine
- Accession number :
- edsair.doi.dedup.....e7fd9775e31a8b2c097c44b3dd65ee9d