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Ambulatory pulse pressure, brain neuronal fiber integrity, and cerebral blood flow in older adults
Ambulatory pulse pressure, brain neuronal fiber integrity, and cerebral blood flow in older adults
- Source :
- J Cereb Blood Flow Metab
- Publication Year :
- 2017
-
Abstract
- Ambulatory blood pressure (ABP) reflects the end-organ vascular stress in daily life; however, its influence on brain neuronal fiber integrity and cerebral blood flow (CBF) remains unclear. The objective of this study was to determine the associations among ABP, white matter (WM) neuronal fiber integrity, and CBF in older adults. We tested 144 participants via ABP monitoring and diffusion tensor imaging. The total level and pulsatile indices of CBF were measured by phase-contrast MRI and transcranial Doppler, respectively. Neuropsychological assessment was conducted in 72 participants. Among ambulatory and office BP measures, elevated 24-h pulse pressure (PP) was associated with the greatest number of WM skeleton voxels with decreased fractional anisotropy (FA) and increased mean diffusivity (MD). Furthermore, these associations remained significant after adjusting for age, antihypertensive use, aortic stiffness, WM lesion volume, and office PP. Radial diffusivity (RD) was elevated in the regions with decreased FA, while axial diffusivity was unaltered. The reduction in diastolic index explained a significant proportion of the individual variability in FA, MD, and RD. Executive function performance was correlated with WM fiber integrity. These findings suggest that elevated ambulatory PP may deteriorate brain neuronal fiber integrity via reduction in diastolic index.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Aging
Ambulatory blood pressure
Pulsatile flow
Blood Pressure
White matter
03 medical and health sciences
Executive Function
0302 clinical medicine
Vascular Stiffness
Internal medicine
Fractional anisotropy
medicine
Humans
Cognitive Dysfunction
Aged
Aged, 80 and over
business.industry
Brain
Original Articles
Blood Pressure Monitoring, Ambulatory
Middle Aged
White Matter
Transcranial Doppler
Pulse pressure
030104 developmental biology
medicine.anatomical_structure
Diffusion Tensor Imaging
Neurology
Cerebral blood flow
Cerebrovascular Circulation
Cardiology
Neurology (clinical)
Cardiology and Cardiovascular Medicine
business
030217 neurology & neurosurgery
Diffusion MRI
Subjects
Details
- ISSN :
- 15597016
- Volume :
- 39
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
- Accession number :
- edsair.doi.dedup.....e7fd367d6173a4b259737ffb375af2db