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Prognostic and clinicopathological roles of programmed death‐ligand 1 ( <scp>PD‐L1</scp> ) expression in thymic epithelial tumors: A meta‐analysis
- Source :
- Thoracic Cancer, Vol 11, Iss 11, Pp 3086-3098 (2020), Thoracic Cancer
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Background Programmed death‐ligand 1 (PD‐L1) is one of the immune checkpoint proteins, and plays an important role in the progression and microenvironment of cancer. PD‐L1 expression has been associated with poor survival in many cancers. Several studies have also shown an association between PD‐L1 expression and the prognosis of patients with thymic epithelial tumors (TETs). In this study, we systematically evaluated the prognostic and clinicopathological roles of PD‐L1 expression in TETs. Methods We searched the literature through PubMed, Embase and Cochrane library and chose the eligible studies, and subsequently performed a meta‐analysis to evaluate the prognostic and clinicopathological roles of PD‐L1 expression in TETs. Results Six of the 75 articles found in the literature were selected. PD‐L1 expression was significantly related to unfavorable overall survival (hazard ratio 1.52, 95% confidence interval [CI]: 1.01–2.30, P = 0.046) in TETs. PD‐L1 expression was significantly associated with male gender (odds ratio [OR] 1.55, 95% CI: 1.08–2.22, P = 0.017) and higher Masaoka stage (OR 3.93, 95% CI: 2.44–6.32, P
- Subjects :
- Male
0301 basic medicine
Pulmonary and Respiratory Medicine
Oncology
medicine.medical_specialty
Cochrane Library
lcsh:RC254-282
B7-H1 Antigen
programmed death‐ligand 1
03 medical and health sciences
0302 clinical medicine
Internal medicine
Tumor Microenvironment
medicine
Humans
Neoplasms, Glandular and Epithelial
Stage (cooking)
business.industry
Hazard ratio
Cancer
Thymus Neoplasms
Original Articles
General Medicine
Odds ratio
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Confidence interval
Immune checkpoint
030104 developmental biology
thymic epithelial tumor
030220 oncology & carcinogenesis
Meta-analysis
Meta‐analysis
Female
Original Article
prognosis
business
Subjects
Details
- ISSN :
- 17597714 and 17597706
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Thoracic Cancer
- Accession number :
- edsair.doi.dedup.....e7f53875f006f3fa7cc75b1779e5dff5