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Sociodemographic changes and trends in the rates of new perinatal HIV diagnoses and transmission in Spain from 1997 to 2015
- Source :
- PLoS ONE, Plos One, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe, instname, PLoS ONE, Vol 14, Iss 10, p e0223536 (2019), Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona, PLoS One, r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu, Fundació Sant Joan de Déu, Scientia, Digital.CSIC. Repositorio Institucional del CSIC, r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
- Publication Year :
- 2019
- Publisher :
- Public Library of Science, 2019.
-
Abstract
- [Background] There are not enough nationwide studies on perinatal HIV transmission in connection with a combination of antiretroviral treatments in Spain. Our objectives were to study sociodemographic changes and trends in the rates of HIV diagnoses and perinatal transmission in Spain from 1997 to 2015.<br />[Methods] A retrospective study using data from Spanish Paediatric HIV Network (CoRISpe) and Spanish Minimum Basic Data Set (MDBS) was performed. HIV- diagnosed children between 1997 and 2015 were selected. Sociodemographic, clinical and immunovirological data of HIV-infected children and their mothers were studied in four calendar periods (P1: 1997–2000; P2: 2001–2005; P3: 2006–2010; P4: 2011–2015). Rates of perinatal HIV diagnoses and transmission from 1997 to 2015 were calculated.<br />[Results] A total of 532 HIV-infected children were included in this study. Of these children, 406 were Spanish (76.3%) and 126 immigrants (23.7%). A decrease in the number of HIV diagnoses, 203 (38.2%) children in the first (P1), 149 (28%) in the second (P2), 130 (24.4%) in the third (P3) and 50 (9.4%) in the fourth (P4) calendar periods was studied. The same decrease in the Spanish HIV-infected children (P1, 174 (46.6%), P2, 115 (30.8%), P3, 65 (17.4%) and P4, 19 (5.1%)) was monitored. However, an increase in the number of HIV diagnoses by sexual contact (P1: 0%; P2: 1.3%; P3: 4.6%; P4: 16%) was observed. The rates of new perinatal HIV diagnoses and perinatal transmission in Spanish children decreased from 0.167 to 0.005 per 100,000 inhabitants and 11.4% to 0.4% between 1997 and 2015, respectively.<br />[Conclusions] A decline of perinatal HIV diagnoses and transmission was observed. However, an increase of teen-agers HIV diagnoses with sexual infection was studied. Public awareness campaigns directed to teen-agers are advisable to prevent HIV infection by sexual contact.<br />This work has been partially funded by Red Temática de Investigación en SIDA (RED RIS) supported by Instituto de Salud Carlos III (ISCIII) (RD12/0017/0035, RD12/0017/0037 and RD16/0025/0019), project as part of the Plan R+D+I (2008–2011; 2013–2016) and cofinanced by ISCIII- Subdirección General de Evaluación and Fondo Europeo de Desarrollo Regional (FEDER), RIS-EPICLIN-19/2015, Fondo para la Investigación Sanitaria of the Spanish Ministry of Science and Innovation (FIS PI13/00422, PI16/01863), CYTED (214RT0482) and EPIICAL Project. CIBER-BBN is an initiative funded by the VI National R&D&I Plan 2008–2011, Iniciativa Ingenio 2010, the Consolider Program, and CIBER Actions and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. COST CA17140 Cancer Nanomedicine-Front The Bench to Bebside. We thank the Spanish HIV HGM BioBank supported by ISC III project RETIC PT13/0010/0028 and PT17/0015/0042. No funding for this work was received from National Institutes of Health (NIH), Wellcome Trust and Howard Hughes Medical Institute (HHMI).
- Subjects :
- 0301 basic medicine
RNA viruses
Male
Perinatal transmission
European People
Spanish People
Epidemiology
Maternal Health
Human immunodeficiency virus (HIV)
HIV Infections
medicine.disease_cause
Pathology and Laboratory Medicine
Severity of Illness Index
Perinatal hiv
Geographical locations
Labor and Delivery
Families
0302 clinical medicine
Immunodeficiency Viruses
Pregnancy
Risk Factors
Medicine
Ethnicities
Public Health Surveillance
030212 general & internal medicine
Medical diagnosis
Hispanic People
Multidisciplinary
Transmission (medicine)
virus diseases
Obstetrics and Gynecology
HIV diagnosis and management
3. Good health
Europe
Geographic Locations::Europe::Spain [GEOGRAPHICALS]
HIV epidemiology
Medical Microbiology
Viral Pathogens
Viruses
Ubicaciones Geográficas::Europa (Continente)::España [DENOMINACIONES GEOGRÁFICAS]
Female
Pathogens
Sexual contact
Research Article
virosis::virosis::enfermedades de transmisión sexual::enfermedades virales de transmisión sexual::infecciones por VIH [ENFERMEDADES]
Pediatric hiv
Science
030106 microbiology
Mothers
Infections::Sexually Transmitted Diseases::Sexually Transmitted Diseases, Viral::HIV Infections [DISEASES]
Microbiology
History, 21st Century
03 medical and health sciences
Retroviruses
Humans
European Union
Microbial Pathogens
Retrospective Studies
Medicine and health sciences
business.industry
Lentivirus
Organisms
Biology and Life Sciences
HIV
Retrospective cohort study
History, 20th Century
Diagnostic medicine
Infectious Disease Transmission, Vertical
Spain
técnicas de investigación::métodos epidemiológicos::características de los estudios epidemiológicos::estudios epidemiológicos::estudios de casos y controles::estudios retrospectivos [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS]
Birth
Women's Health
Infeccions per VIH
Population Groupings
Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics::Epidemiologic Studies::Case-Control Studies::Retrospective Studies [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT]
People and places
business
Estudi de casos - Espanya
Demography
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 14
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....e7e8ac3661a7ba123a671ddb930b9992