Response to Vaccination in Infants Exposed to Antitumor Necrosis Factor Alpha In Utero

In this retrospective cohort study, the response to routinely administered Haemophilus influenzae type B vaccine, pneumococcal and pertussis vaccinations in 27 children exposed to antitumor necrosis factor alpha (anti-TNF alpha) during pregnancy was measured. The overall vaccination response seems comparable for children exposed to anti-TNF alpha and healthy infants. After primary vaccination series, inadequate response was present in some patients and might be related to exposure to anti-TNF alpha.