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Parental psychological distress during pregnancy and wheezing in preschool children: The Generation R Study
- Source :
- Journal of Allergy and Clinical Immunology, 133(1), 59-+. Mosby Inc., Journal of Allergy and Clinical Immunology; Vol 133
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Background Maternal psychological distress during pregnancy might affect fetal lung development and subsequently predispose children to childhood asthma. Objective We sought to assess the associations of maternal psychological distress during pregnancy with early childhood wheezing. Methods We performed a population-based prospective cohort study among 4848 children. We assessed maternal and paternal psychological distress at the second trimester of gestation and 3 years after delivery and maternal psychological distress at 2 and 6 months after delivery by using the Brief Symptom Inventory questionnaire. Wheezing in the children was annually examined by using questionnaires from 1 to 4 years. Physician-diagnosed ever asthma was reported at 6 years. Results Mothers with psychological distress during pregnancy had increased odds of wheezing in their children from 1 to 4 years of life (overall distress: odds ratio [OR], 1.60 [95% CI, 1.32-1.93]; depression: OR, 1.46 [95% CI, 1.20-1.77]; and anxiety: OR, 1.39 [95% CI, 1.15-1.67]). We observed similar positive associations with the number of wheezing episodes, wheezing patterns, and physician-diagnosed asthma at 6 years. Paternal distress during pregnancy and maternal and paternal distress after delivery did not affect these results and were not associated with childhood wheezing. Conclusion Maternal psychological distress during pregnancy is associated with increased odds of wheezing in their children during the first 6 years of life independent of paternal psychological distress during pregnancy and maternal and paternal psychological distress after delivery. These results suggest a possible intrauterine programming effect of maternal psychological distress leading to respiratory morbidity.
- Subjects :
- Male
Pediatrics
medicine.medical_specialty
Immunology
Population
Mothers
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Pregnancy
Humans
Immunology and Allergy
Medicine
Prospective Studies
030212 general & internal medicine
Child
education
Respiratory Sounds
Asthma
education.field_of_study
business.industry
Infant, Newborn
Infant
Odds ratio
medicine.disease
3. Good health
Pregnancy Complications
Distress
030228 respiratory system
Maternal Exposure
Child, Preschool
Prenatal Exposure Delayed Effects
Paternal Exposure
Anxiety
Female
Generation R
medicine.symptom
business
Stress, Psychological
Follow-Up Studies
Cohort study
Subjects
Details
- ISSN :
- 00916749
- Volume :
- 133
- Database :
- OpenAIRE
- Journal :
- Journal of Allergy and Clinical Immunology
- Accession number :
- edsair.doi.dedup.....e7d13c80df18a369a5ed1c23b780bc49