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Oral Andro-Related Prohormone Supplementation: Do the Potential Risks Outweigh the Benefits?

Authors :
Craig E. Broeder
Source :
Canadian Journal of Applied Physiology. 28:102-116
Publication Year :
2003
Publisher :
Canadian Science Publishing, 2003.

Abstract

Androstenedione, 4-androstenediol, 5-androstenediol, 19-norandrostenediol and 19-norandrostenedione are commonly referred to as "Andro" prohormones. Over the last few years, supplementation using these prohormones has been aggressively marketed to the general public. Supplement manufacturers often claim that Andro use improves serum testosterone concentrations, increases muscular strength and muscle mass, helps to reduce body fatness, enhances mood, and improves sexual performance. However, to date, most studies contradict these claims. In contrast, several studies using oral Andro related prohormones show that Andro use can abnormally elevate estrogen related hormones as well as alterations in hormonal markers (i.e., abnormal elevations in serum estrogen) thought to increase a person's risk for developing prostate or pancreatic cancers. In addition, most studies also indicate that significant declines in high-density lipoproteins occur leading to an increased cardiovascular disease risk. Thus, to date, the current research base suggests that Andro prohormone use does not support manufacturer claims. But it does suggest there should be strong concerns regarding long-term oral Andro prohormone use, especially regarding its effects on blood lipids and estrogen hormone profiles. Key words: resistance exercise, androstenedione, androstenediol, anti-aging

Details

ISSN :
10667814
Volume :
28
Database :
OpenAIRE
Journal :
Canadian Journal of Applied Physiology
Accession number :
edsair.doi.dedup.....e7cdff30866974cb1361cbb6704dc029
Full Text :
https://doi.org/10.1139/h03-009