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Inflammatory Gene Expression in Neck Perivascular and Subcutaneous Adipose Tissue in Men With Carotid Stenosis
Inflammatory Gene Expression in Neck Perivascular and Subcutaneous Adipose Tissue in Men With Carotid Stenosis
- Source :
- Angiology. 73(3)
- Publication Year :
- 2021
-
Abstract
- The inflammatory phenotype of neck adipose tissue (NAT) might reflect its involvement in the pathogenesis of carotid atherosclerosis. We investigated inflammatory gene expression in the subcutaneous and the perivascular (pericarotid) adipose tissue from patients with carotid stenosis (CS) undergoing endarterectomy and a control group of patients without significant carotid atherosclerosis undergoing thyroid surgery. Only male patients were included (n = 13 in each study group). Clinical and biochemical data along with serum leptin, adiponectin, and monocyte chemoattractant protein 1 (MCP-1) were collected. Adipose tissue samples were obtained from both the subcutaneous and pericarotid compartments. Real-time polymerase chain reaction was used to measure gene expression of macrophage markers and adipokines. The CS group had higher subcutaneous and pericarotid visfatin gene expression and higher pericarotid expression of MCP-1 and CD68 genes. The ratio between pericarotid CD206 and CD68 gene expression was similar between study groups. Adiponectin gene expression in both NAT compartments did not differ between groups, but it was negatively associated with body weight. These observations suggest that NAT, and especially the pericarotid compartment, express enhanced inflammatory properties in patients with CS, but the proportion of anti-inflammatory macrophages in advanced atherosclerosis seems to be maintained.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Subcutaneous Fat
Adipokine
Adipose tissue
Antigens, Differentiation, Myelomonocytic
Gene Expression
Inflammation
030204 cardiovascular system & hematology
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Adipokines
Antigens, CD
Gene expression
Medicine
Humans
Carotid Stenosis
Chemokine CCL2
030304 developmental biology
0303 health sciences
Adiponectin
business.industry
CD68
Thyroid
medicine.anatomical_structure
Adipose Tissue
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Neck
Subjects
Details
- ISSN :
- 19401574
- Volume :
- 73
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Angiology
- Accession number :
- edsair.doi.dedup.....e7c087e7d5eb23757394ef8d9b914476