The Aspergillus fumigatus P-Type Golgi Apparatus Ca2+/Mn2+ ATPase PmrA Is Involved in Cation Homeostasis and Cell Wall Integrity but Is Not Essential for Pathogenesis ▿

The Aspergillus fumigatus Δ pmrA (Golgi apparatus Ca 2+ /Mn 2+ P-type ATPase) strain has osmotically suppressible basal growth defects and cationic tolerance associated with increased expression of calcineurin pathway genes. Despite increased β-glucan and chitin content, it is hypersensitive to cell wall inhibitors but remains virulent, suggesting a role for PmrA in cation homeostasis and cell wall integrity.