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Local and Systemic Oxidative Stress in Balkan Endemic Nephropathy Is Not Associated with Xanthine Oxidase Activity
- Source :
- Oxidative Medicine and Cellular Longevity, Vol 2020 (2020), Oxidative Medicine and Cellular Longevity
- Publication Year :
- 2020
- Publisher :
- Hindawi Limited, 2020.
-
Abstract
- Balkan endemic nephropathy (BEN) represents a chronic tubulointerstitial nephropathy which is followed by the progression of kidney fibrosis to end-stage kidney failure. The critical involvement of poisons in food (aristolochic acid (AA), ochratoxin, and heavy metals) and selenium deficiency are among nutritive factors which contribute to the pathogenesis of BEN, due to reactive oxygen species (ROS) liberation and/or decreased antioxidative defence system. The aim of the study is to distinguish a possible systemic and local origin of ROS through the measurement of xanthine oxidase (XO) activity in urine and plasma, along with the determination of the oxidative changes in lipids and proteins. The study included 50 patients with BEN and 38 control healthy subjects. We noted increased levels of both thiobarbituric acid-reactive substances (TBARS) and advanced oxidation protein products (AOPPs) in the plasma of patients with BEN, compared to the control group (p<0.001). The urinary levels of AOPPs were higher in patients with BEN in comparison to the control (p<0.001). The specific activity of XO was significantly lower in plasma and urine in BEN samples, compared to controls (p<0.005). Based on these results, we hypothesize that XO might not be considered a direct systemic or local contributor to ROS production in BEN, most probably because of the diminished kidney functional tissue mass and/or AA-induced changes in purine nucleotide conformation. The increased AOPP and TBARS level in both plasma and urine in BEN may predict ROS systemic liberation with toxic local effects.
- Subjects :
- Male
0301 basic medicine
Purine
Xanthine Oxidase
Aging
medicine.medical_specialty
Article Subject
Balkan Nephropathy
030232 urology & nephrology
Aristolochic acid
medicine.disease_cause
Thiobarbituric Acid Reactive Substances
Biochemistry
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Selenium deficiency
Internal medicine
medicine
TBARS
Humans
Xanthine oxidase
Aged
Aged, 80 and over
chemistry.chemical_classification
Kidney
Reactive oxygen species
QH573-671
Chemistry
Cell Biology
General Medicine
Middle Aged
medicine.disease
Oxidative Stress
030104 developmental biology
medicine.anatomical_structure
Endocrinology
Case-Control Studies
Female
Cytology
Oxidation-Reduction
Oxidative stress
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 19420994 and 19420900
- Volume :
- 2020
- Database :
- OpenAIRE
- Journal :
- Oxidative Medicine and Cellular Longevity
- Accession number :
- edsair.doi.dedup.....e7bb3615215a1d7a9b130a6c2a2afbf8