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Comparison of the expression of cluster of differentiation (CD)39 and CD73 between propofol- and sevoflurane-based anaesthesia during open heart surgery
- Source :
- Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018), Scientific Reports
- Publication Year :
- 2018
- Publisher :
- Nature Portfolio, 2018.
-
Abstract
- High expression of cluster of differentiation (CD)39 and CD73 has cardio-protective effects. We hypothesised that the expression of CD39 and CD73 would differ between propofol- and volatile anaesthetic-based anaesthesia in patients undergoing open heart surgery (OHS). The objective of this prospective randomized trial was to compare the changes in CD39 and CD73 levels in CD4+ T cells between propofol- and sevoflurane-based anaesthesia during OHS. The study randomly allocated 156 patients undergoing OHS to a propofol or sevoflurane group. Blood was obtained preoperatively and up to 48 hours after weaning from cardiopulmonary bypass (CPB). The expression levels of CD39 and CD73 in circulating CD4+ T cells, serum cytokines and other laboratory parameters were analysed. The primary outcome was the expression of CD39 and CD73 on CD4+ T cells. Demographic data and perioperative haemodynamic changes did not show significant differences between the two groups. The expression of CD39 and CD73 in the sevoflurane group was significantly lower than in the propofol group (P + T cells compared to sevoflurane-based anaesthesia during OHS.
- Subjects :
- Adult
CD4-Positive T-Lymphocytes
Male
medicine.medical_specialty
Tetraspanins
medicine.medical_treatment
Science
Hemodynamics
030204 cardiovascular system & hematology
Article
Sevoflurane
law.invention
03 medical and health sciences
0302 clinical medicine
Antigens, Neoplasm
030202 anesthesiology
law
medicine
Cardiopulmonary bypass
Humans
Weaning
Prospective Studies
Cardiac Surgical Procedures
Propofol
Aged
Cardiopulmonary Bypass
Multidisciplinary
Cluster of differentiation
business.industry
Apyrase
Perioperative
Middle Aged
Surgery
Cytokine
Gene Expression Regulation
Anesthesia
Anesthetics, Inhalation
Cytokines
Medicine
Female
business
Anesthetics, Intravenous
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 8
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....e7b48219a713416966c8fb581f467e1a