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Birth weight, gestational age and risk of cardiovascular disease in early adulthood: Influence of familial factors
- Source :
- American journal of epidemiology.
- Publication Year :
- 2022
-
Abstract
- The association between intrauterine growth restriction (IUGR) and cardiovascular disease (CVD) later in life might be confounded by familial factors. We conducted a bi-national register-based cohort study to assess associations of birthweight for gestational age (GA), a proxy for IUGR, and GA with CVD risk in early adulthood, before and after addressing familial factors via sibling comparison. We included 3,410,334 live non-malformed singleton births in Sweden (1973-1996) and Denmark (1978-1998). During a median follow-up of 10 years from age 18 onwards, 29,742 individuals developed incident CVD (hypertensive, ischemic heart, and cerebrovascular diseases). Compared with individuals born with appropriate birthweight for GA (AGA, 10th-90th percentiles) or full term (39-40 gestational weeks), individuals born severely small for GA (SGA
- Subjects :
- Epidemiology
Subjects
Details
- ISSN :
- 14766256
- Database :
- OpenAIRE
- Journal :
- American journal of epidemiology
- Accession number :
- edsair.doi.dedup.....e7b41803c135ec238c3bbf81f303c964