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Leucine-rich alpha 2 glycoprotein is a new marker for active disease of tuberculosis
- Source :
- Scientific Reports, Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
- Publication Year :
- 2019
-
Abstract
- Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is a global health problem. At present, prior exposure to Mtb can be determined by blood-based interferon-gamma release assay (IGRA), but active TB is not always detectable by blood tests such as CRP and ESR. This study was undertaken to investigate whether leucine-rich alpha-2 glycoprotein (LRG), a new inflammatory biomarker, could be used to assess active disease of TB. Cynomolgus macaques pretreated with or without Bacille Calmette-Guerin (BCG) vaccination were inoculated with Mtb to induce active TB. Blood was collected over time from these animals and levels of LRG as well as CRP and ESR were quantified. In the macaques without BCG vaccination, Mtb inoculation caused extensive TB and significantly increased plasma CRP and LRG levels, but not ESR. In the macaques with BCG vaccination, whereas Mtb challenge caused pulmonary TB, only LRG levels were significantly elevated. By immunohistochemical analysis of the lung, LRG was visualized in epithelioid cells and giant cells of the granulation tissue. In humans, serum LRG levels in TB patients were significantly higher than those in healthy controls and declined one month after anti-tubercular therapy. These findings suggest that LRG is a promising biomarker when performed following IGRA for the detection of active TB.
- Subjects :
- 0301 basic medicine
Tuberculosis
lcsh:Medicine
Blood Sedimentation
Article
Mycobacterium tuberculosis
03 medical and health sciences
0302 clinical medicine
medicine
Animals
Humans
lcsh:Science
Lung
Glycoproteins
Multidisciplinary
biology
business.industry
Interleukin-6
lcsh:R
Diagnostic markers
biology.organism_classification
medicine.disease
Vaccination
Disease Models, Animal
Macaca fascicularis
030104 developmental biology
medicine.anatomical_structure
C-Reactive Protein
Giant cell
030220 oncology & carcinogenesis
Case-Control Studies
Immunology
BCG Vaccine
Biomarker (medicine)
Immunohistochemistry
lcsh:Q
business
Epithelioid cell
Biomarkers
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 10
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific reports
- Accession number :
- edsair.doi.dedup.....e79ea04db9606f859d75dd0afdf37a80