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The role of pro-inflammatory factors in mediating the effects on the fetus of prenatal undernutrition: Implications for schizophrenia
- Source :
- Schizophrenia Research. 99:48-55
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- Exposure to prenatal undernutrition or malnutrition increases the risk of schizophrenia, although little is known about the mechanism. Pro-inflammatory factors are critical in brain development, and are believed to play an important role in neurodevelopmental disorders associated with prenatal exposure to infection, including schizophrenia. However it is not known whether pro-inflammatory factors also mediate the effects on the fetus of prenatal malnutrition or undernutrition. In this study, we established a new prenatal undernourished rat model induced by maternal exposure to a diet restricted to 50% of the low (6%) protein diet (RLP50). We observed the disappearance of maternal nest-building behavior in the RLP50 dams, increased levels of TNFA and IL6 in the placentas (P
- Subjects :
- Psychosis
medicine.medical_specialty
Placenta
Physiology
Enzyme-Linked Immunosorbent Assay
Protein-Energy Malnutrition
Nesting Behavior
Rats, Sprague-Dawley
Pregnancy
medicine
Animals
Humans
Maternal Behavior
Biological Psychiatry
Prenatal undernutrition
Fetus
Interleukin-6
Tumor Necrosis Factor-alpha
Malnutrition
Brain
Prenatal malnutrition
medicine.disease
Rats
Surgery
Disease Models, Animal
Psychiatry and Mental health
medicine.anatomical_structure
Liver
Schizophrenia
Prenatal Exposure Delayed Effects
Cytokines
Female
Tumor necrosis factor alpha
Psychology
Subjects
Details
- ISSN :
- 09209964
- Volume :
- 99
- Database :
- OpenAIRE
- Journal :
- Schizophrenia Research
- Accession number :
- edsair.doi.dedup.....e798fa8b238cd99e9863488c93573384