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The role of pro-inflammatory factors in mediating the effects on the fetus of prenatal undernutrition: Implications for schizophrenia

Authors :
Lin He
Lingfang Yu
G. Y. Feng
D. St Clair
Ti Wang
X.Z. Zhao
Zhiqiang Li
Q. Shen
Chunling Wan
Sh. Li
Xing Wang Li
Yu Sun
Source :
Schizophrenia Research. 99:48-55
Publication Year :
2008
Publisher :
Elsevier BV, 2008.

Abstract

Exposure to prenatal undernutrition or malnutrition increases the risk of schizophrenia, although little is known about the mechanism. Pro-inflammatory factors are critical in brain development, and are believed to play an important role in neurodevelopmental disorders associated with prenatal exposure to infection, including schizophrenia. However it is not known whether pro-inflammatory factors also mediate the effects on the fetus of prenatal malnutrition or undernutrition. In this study, we established a new prenatal undernourished rat model induced by maternal exposure to a diet restricted to 50% of the low (6%) protein diet (RLP50). We observed the disappearance of maternal nest-building behavior in the RLP50 dams, increased levels of TNFA and IL6 in the placentas (P

Details

ISSN :
09209964
Volume :
99
Database :
OpenAIRE
Journal :
Schizophrenia Research
Accession number :
edsair.doi.dedup.....e798fa8b238cd99e9863488c93573384