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Signal-transducing adaptor protein-1 and protein-2 in hematopoiesis and diseases
- Source :
- Experimental Hematology. 105:10-17
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- Inflammatory and immune signals are involved in stressed hematopoiesis under myeloablation, infection, chronic inflammation, and aging. These signals also affect malignant pathogenesis, and the dysregulated immune environment which causes the resistance to treatment. Upon activation, various types of protein tyrosine kinases in the cytoplasm mediate the cascade, leading to the transcription of target genes in the nucleus. Adaptor molecules are commonly defined as proteins, that lack enzymatic activity, DNA-binding or receptor functions, and possess protein-protein or protein-lipid interaction domains. By binding to specific domains of signaling molecules, adaptor proteins adjust the signaling responses after the ligation of receptors of soluble factors, including cytokines, chemokines, and growth factors, as well as pattern recognition receptors such as toll-like receptors. Signal-transducing adaptor protein (STAP) family regulates various intracellular signaling pathways. These proteins have a pleckstrin homology domain in the N-terminal region and SRC-homology 2-like domain in the central region, representing typical binding structures as adapter proteins. Following the elucidation of the effects of STAPs on terminally differentiated immune cells, such as macrophages, T cells, mast cells, and basophils, recent findings have shown the critical roles of STAP-2 in B cell progenitor cells in marrow under hematopoietic stress and STAP-1 and -2 in BCR-ABL-transduced leukemogenesis. In this review, we focus on the role of STAPs in the bone marrow.
- Subjects :
- Cancer Research
Chemokine
Cell signaling
biology
Chemistry
Pattern recognition receptor
Signal transducing adaptor protein
Cell Biology
Hematology
Phosphoproteins
Hematopoiesis
Cell biology
Pleckstrin homology domain
Signal-Transducing Adaptor Protein 1
Immune system
Bone Marrow
Hematologic Neoplasms
Genetics
biology.protein
Animals
Humans
Receptor
Molecular Biology
Adaptor Proteins, Signal Transducing
Signal Transduction
Subjects
Details
- ISSN :
- 0301472X
- Volume :
- 105
- Database :
- OpenAIRE
- Journal :
- Experimental Hematology
- Accession number :
- edsair.doi.dedup.....e79402cc844b023558f987b8cc5796c7