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The Role of Isoflavones in Type 2 Diabetes Prevention and Treatment—A Narrative Review
- Source :
- International Journal of Molecular Sciences, Vol 22, Iss 218, p 218 (2021), International Journal of Molecular Sciences
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Given the growing number of type 2 diabetic individuals and the substantial social and financial costs associated with diabetes management, every effort should be made to improve its prevention and treatment methods. There is an ongoing search for natural dietary compounds that could be used for this purpose. This narrative review focuses on the therapeutic potential of isoflavones in diabetes prevention and treatment. This review summarizes (i) the molecular mechanisms of isoflavones action that are critical to their anti-diabetic properties; (ii) preclinical (in vitro and in vivo) studies evaluating the influence of isoflavones on the function of key organs involved in the pathogenesis of diabetes; and (iii) epidemiological studies and clinical trials that assessed the effectiveness of isoflavones in the prevention and treatment of type 2 diabetes in humans. Apart from discussing the effects of isoflavones on the function of organs “classically” associated with the pathogenesis of diabetes (pancreas, liver, muscles, and adipose tissue), the impact of these compounds on other organs that contribute to the glucose homeostasis (gastrointestinal tract, kidneys, and brain) is also reviewed.
- Subjects :
- 0301 basic medicine
biochanin A
Genistein
030209 endocrinology & metabolism
Type 2 diabetes
Review
Bioinformatics
formononetin
Catalysis
Inorganic Chemistry
genistein
lcsh:Chemistry
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Diabetes management
Diabetes mellitus
medicine
Glucose homeostasis
Humans
Physical and Theoretical Chemistry
isoflavones
Molecular Biology
lcsh:QH301-705.5
Spectroscopy
Clinical Trials as Topic
business.industry
Organic Chemistry
Daidzein
General Medicine
Isoflavones
medicine.disease
Computer Science Applications
Clinical trial
030104 developmental biology
chemistry
Diabetes Mellitus, Type 2
lcsh:Biology (General)
lcsh:QD1-999
Organ Specificity
glyctin
Disease Progression
type 2 diabetes
daidzein
business
Subjects
Details
- Language :
- English
- ISSN :
- 16616596 and 14220067
- Volume :
- 22
- Issue :
- 218
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....e78ffec519a0f0bfea51929b32e0afcf