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Evaluation of Heart-type Fatty Acid-binding Protein in Early Diagnosis of Acute Myocardial Infarction
- Source :
- Journal of Korean Medical Science
- Publication Year :
- 2021
- Publisher :
- Korean Academy of Medical Sciences, 2021.
-
Abstract
- Background Although electrocardiography and cardiac troponin play important roles in the diagnosis of acute coronary syndrome (ACS), there remain unmet clinical needs. Heart-type fatty acid-binding protein (H-FABP) has been identified as an early diagnostic marker of acute myocardial infarction (AMI). In this study, we examined the diagnostic and prognostic value of H-FABP in patients suspected with ACS. Methods We conducted an observational single-center cohort study, including 89 adults aged 30 years or older, who presented to the emergency room (ER) within 24 hours after the onset of chest pain and/or dyspnea. We performed laboratory analysis and point-of-care testing (POCT) for cardiac markers, including H-FABP, troponin I, and creatine kinase-myocardial band. We also evaluated the correlation between cardiac markers and left ventricular (LV) dysfunction and extent of coronary artery disease (CAD). Results In patients presented to ER within 4 hours after symptom onset (n = 49), the diagnostic accuracy of H-FABP for AMI, as quantified by the area under the receiver operating characteristic curve, was higher (0.738; 95% confidence interval [CI], 0.591–0.885) than other cardiac markers. In POCT, the diagnostic accuracy of H-FABP (56%; 95% CI, 45–67) was significantly higher than other cardiac markers. H-FABP was correlated with not extent of CAD but post-AMI LV dysfunction. Conclusion H-FABP is a useful cardiac marker for the early diagnosis of AMI and prediction of myocardia injury. Difference in the circulatory release timeline of cardiac markers could explain its utility in early-stage of myocardial injury.<br />Graphical Abstract
- Subjects :
- Adult
Male
Chest Pain
Heart-type Fatty Acid-binding Protein
Acute coronary syndrome
medicine.medical_specialty
Point-of-Care Systems
Cardiovascular Disorders
Cardiac marker
Myocardial Infarction
Chest pain
Sensitivity and Specificity
Cohort Studies
Coronary artery disease
03 medical and health sciences
0302 clinical medicine
Internal medicine
Troponin I
Acute Myocardial Infarction
medicine
Creatine Kinase, MB Form
Humans
030212 general & internal medicine
Myocardial infarction
Aged
medicine.diagnostic_test
business.industry
General Medicine
Middle Aged
Prognosis
medicine.disease
ROC Curve
Area Under Curve
Cardiac Troponin I
Heart-type fatty acid binding protein
Acute Disease
Cardiology
Female
Original Article
lipids (amino acids, peptides, and proteins)
medicine.symptom
Emergency Service, Hospital
business
Fatty Acid Binding Protein 3
Electrocardiography
Biomarkers
Creatinine Kinase-myocardial Band
Subjects
Details
- ISSN :
- 15986357 and 10118934
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Journal of Korean Medical Science
- Accession number :
- edsair.doi.dedup.....e78d11e0c35b777452e504f0be26fbb1