Back to Search
Start Over
γ-Parvin Is Dispensable for Hematopoiesis, Leukocyte Trafficking, and T-Cell-Dependent Antibody Response†
- Source :
- Molecular and Cellular Biology (Washington, DC)
- Publication Year :
- 2006
- Publisher :
- American Society for Microbiology, 2006.
-
Abstract
- Integrins regulate cell behavior through the assembly of multiprotein complexes at the site of cell adhesion. Parvins are components of such a multiprotein complex. They consist of three members (alpha-, beta-, and gamma-parvin), form a functional complex with integrin-linked kinase (ILK) and PINCH, and link integrins to the actin cytoskeleton. Whereas alpha- and beta-parvins are widely expressed, gamma-parvin has been reported to be expressed in hematopoietic organs. In the present study, we report the expression pattern of the parvins in hematopoietic cells and the phenotypic analysis of gamma-parvin-deficient mice. Whereas alpha-parvin is not expressed in hematopoietic cells, beta-parvin is only found in myeloid cells and gamma-parvin is present in both cells of the myeloid and lymphoid lineages, where it binds ILK. Surprisingly, loss of gamma-parvin expression had no effect on blood cell differentiation, proliferation, and survival and no consequence for the T-cell-dependent antibody response and lymphocyte and dendritic cell migration. These data indicate that despite the high expression of gamma-parvin in hematopoietic cells it must play a more subtle role for blood cell homeostasis.
- Subjects :
- Myeloid
T cell
Cellular differentiation
T-Lymphocytes
Integrin
Biology
Blood cell
Mice
Cell Movement
Reference Values
medicine
Leukocytes
Animals
Actinin
Lymphocytes
Cell adhesion
Dendritic cell migration
Molecular Biology
Mice, Knockout
Macrophages
Microfilament Proteins
Cell Differentiation
Cell Biology
Articles
Dendritic Cells
Actin cytoskeleton
Molecular biology
Cell biology
Hematopoiesis
Up-Regulation
medicine.anatomical_structure
Fertility
biology.protein
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Molecular and Cellular Biology (Washington, DC)
- Accession number :
- edsair.doi.dedup.....e78bf71469bc86cf2e4f5abdf2555eef