Epidural Fentanyl Counteracts Sympathetic Gastric Inhibition

Postoperative paralytic ileus is in part mediated by the sympathetic gastrointestino-gastrointestinal (GI-GI) reflex. The modulation of this reflex by epidural fentanyl (50 micrograms) was studied in chloralose-anesthetized, ventilated cats. The vagi were cut in the neck but could be efferently stimulated. Gastric volume, arterial pressure and heart rate were followed and the GI-GI reflex was elicited by intestinal distension, mesenteric afferent nerve stimulation or heating or capsaicin administered intra-arterially to an intestinal loop. Epidural fentanyl enhanced the gastric contraction response to efferent vagal stimulation and considerably counter-acted the GI-GI reflex inhibition of vagally induced tone. These effects were reversed by epidural naloxone (10 micrograms). In contrast, 50 micrograms of fentanyl i.v. only enhanced the effect of vagal stimulation but had no influence on the inhibitory GI-GI reflex responses. Apparently, epidural fentanyl may inhibit the GI-GI reflex by a spinal point of action.