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Long-term effects of dalfampridine in patients with multiple sclerosis
- Source :
- Journal of the Neurological Sciences. 337:18-24
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Background/objective Dalfampridine is the extended-release formulation of 4-aminopyridine and is approved for the symptomatic treatment of impaired mobility in patients with multiple sclerosis. Our aim was to examine the short- and long-term effects of treatment with dalfampridine on motoric and cognitive assessment parameters of multiple sclerosis (MS) patients over 9–12 months. Methods Fifty-two patients with MS with an EDSS between 4.0 and 7.0 and impaired mobility were evaluated for parameters of walking ability, MSFC, cognitive and motor fatigue and evoked potentials at treatment initiation with dalfampridine as well as 2 weeks and after 9–12 months later. Results Thirty out of fifty-two patients (~ 60%) were still on treatment after 9–12 months. Two weeks after treatment initiation, significant ameliorations could be found for T25FW, maximum walking distance as well as motoric and cognitive fatigue which still persisted after 9–12 months. In contrast significant effects for velocity were observed only after 2 weeks, for improvement in PASAT only after 9–12 months. A tendency for improvement of somatosensory evoked potentials was found in a subset of patients. Conclusion Dalfampridine shows positive short- and long-term effects on motoric and cognitive assessment parameters in an open-label observational study in a cohort of patients with MS.
- Subjects :
- Male
medicine.medical_specialty
Multiple Sclerosis
Time Factors
Symptomatic treatment
Walking
Severity of Illness Index
Statistics, Nonparametric
Disability Evaluation
Drug Delivery Systems
Physical medicine and rehabilitation
Potassium Channel Blockers
medicine
Humans
In patient
4-Aminopyridine
Evoked Potentials
Multiple sclerosis
Electroencephalography
Cognition
Middle Aged
medicine.disease
Neurology
Somatosensory evoked potential
Cohort
Physical therapy
Female
Observational study
Neurology (clinical)
Cognitive Assessment System
Cognition Disorders
Psychology
Follow-Up Studies
Subjects
Details
- ISSN :
- 0022510X
- Volume :
- 337
- Database :
- OpenAIRE
- Journal :
- Journal of the Neurological Sciences
- Accession number :
- edsair.doi.dedup.....e7813244285016a401bbadef12fdbcb4