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Origin and Evolution of Fusidane-Type Antibiotics Biosynthetic Pathway through Multiple Horizontal Gene Transfers
- Source :
- Genome Biol Evol
- Publication Year :
- 2020
- Publisher :
- Oxford University Press (OUP), 2020.
-
Abstract
- Fusidane-type antibiotics represented by fusidic acid, helvolic acid, and cephalosporin P1 have very similar core structures, but they are produced by fungi belonging to different taxonomic groups. The origin and evolution of fusidane-type antibiotics biosynthetic gene clusters (BGCs) in different antibiotics producing strains remained an enigma. In this study, we investigated the distribution and evolution of the fusidane BGCs in 1,284 fungal genomes. We identified 12 helvolic acid BGCs, 4 fusidic acid BGCs, and 1 cephalosporin P1 BGC in Pezizomycotina fungi. Phylogenetic analyses indicated six horizontal gene transfer (HGT) events in the evolutionary trajectory of the BGCs, including 1) three transfers across Eurotiomycetes and Sordariomycetes classes; 2) one transfer between genera under Sordariomycetes class; and 3) two transfers within Aspergillus genus under Eurotiomycetes classes. Finally, we proposed that the ancestor of fusidane BGCs would be originated from the Zoopagomycota by ancient HGT events according to the phylogenetic trees of key enzymes in fusidane BGCs (OSC and P450 genes). Our results extensively clarify the evolutionary trajectory of fusidane BGCs by HGT among distantly related fungi and provide new insights into the evolutionary mechanisms of metabolic pathways in fungi.
- Subjects :
- Gene Transfer, Horizontal
Genome
03 medical and health sciences
0302 clinical medicine
Cytochrome P-450 Enzyme System
Genetics
Intramolecular Transferases
Gene
Ecology, Evolution, Behavior and Systematics
030304 developmental biology
0303 health sciences
biology
Phylogenetic tree
Fungi
Sordariomycetes
biology.organism_classification
Biological Evolution
Anti-Bacterial Agents
Biosynthetic Pathways
Metabolic pathway
Eurotiomycetes
Multigene Family
Horizontal gene transfer
Genome, Fungal
Fusidic Acid
030217 neurology & neurosurgery
Pezizomycotina
Research Article
Subjects
Details
- ISSN :
- 17596653
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Genome Biology and Evolution
- Accession number :
- edsair.doi.dedup.....e7606eedd39d5b18d18daa847e186b00