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Role of adrenal renin-angiotensin system in the control of aldosterone secretion in sodium-restricted rats
Role of adrenal renin-angiotensin system in the control of aldosterone secretion in sodium-restricted rats
- Publication Year :
- 2000
-
Abstract
- This study examined the effect of the pharmacological manipulation of adrenal renin-angiotensin system (RAS) on aldosterone secretion from in situ perfused adrenals of rats kept on a normal diet and sodium restricted for 14 days. Neither the angiotensin-converting enzyme inhibitor captopril nor the nonselective angiotensin II receptor antagonist saralasin and the AT1 receptor-selective antagonist losartan affected basal aldosterone output in normally fed rats. In contrast, they concentration dependently decreased aldosterone secretion in sodium-restricted animals, with maximal effective concentration ranging from 10− 7 to 10− 6 M. Captopril (10− 6 M), saralasin (10− 6 M), and losartan (10− 7 M) counteracted aldosterone response to 10 mM K+ in sodium-restricted rats but not in normally fed animals. Collectively, these findings provide evidence that adrenal RAS plays a role in the regulation of aldosterone secretion, but only under conditions of prolonged stimulation of zona glomerulosa probably leading to overexpression of adrenal RAS.
- Subjects :
- Male
medicine.medical_specialty
Captopril
Normal diet
Physiology
medicine.drug_class
Endocrinology, Diabetes and Metabolism
Sodium
chemistry.chemical_element
Angiotensin-Converting Enzyme Inhibitors
Biology
Receptor, Angiotensin, Type 2
Losartan
Receptor, Angiotensin, Type 1
Renin-Angiotensin System
chemistry.chemical_compound
Angiotensin Receptor Antagonists
Physiology (medical)
Internal medicine
Renin–angiotensin system
Adrenal Glands
medicine
Animals
Secretion
Rats, Wistar
Aldosterone
Adrenal cortex
Diet, Sodium-Restricted
Rats
medicine.anatomical_structure
Endocrinology
chemistry
Mineralocorticoid
Zona glomerulosa
Potassium
Saralasin
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....e74cf9df21b95c3494d0bf1b53b4ff97