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Does depressed persons with non-cardiovascular morbidity have a higher risk of CVD? A population-based cohort study in Sweden
- Source :
- BMC Cardiovascular Disorders, BMC Cardiovascular Disorders, Vol 19, Iss 1, Pp 1-8 (2019)
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Background Depression often co-exists with non-cardiovascular morbid conditions. Whether this comorbidity increases the risk of cardiovascular disease has so far not been studied. Thus, the aim of this study was to determine if non-cardiovascular morbidity modifies the effect of depression on future risk of CVD. Methods Data was derived from the PART study (acronym in Swedish for: Psykisk hälsa, Arbete och RelaTioner: Mental Health, Work and Relationships), a longitudinal cohort study on mental health, work and relations, including 10,443 adults (aged 20–64 years). Depression was assessed using the Major Depression Inventory (MDI) and self-reported data on non-cardiovascular morbidity was assessed in 1998–2000. Outcomes of CVD were assessed using the National Patient Register during 2001–2014. Results Both depression (HR 1.5 (95% CI, 1.1, 2.0)) and non-cardiovascular morbidity (HR 2.0 (95% CI, 1.8, 2.6)) were associated with an increased future risk of CVD. The combined effect of depression and non-cardiovascular comorbidity on future CVD was HR 2.1 (95%, CI 1.3, 3.4) after adjusting for age, gender and socioeconomic position. Rather similar associations were seen after further adjustment for hypertension, diabetes and unhealthy lifestyle factors. Conclusion Persons affected by depression in combination with non-cardiovascular morbidity had a higher risk of CVD compared to those without non-cardiovascular morbidity or depression alone.
- Subjects :
- Adult
Male
lcsh:Diseases of the circulatory (Cardiovascular) system
medicine.medical_specialty
Time Factors
Major Depression Inventory
Comorbidity
Disease
Risk Assessment
Young Adult
Population based cohort
Risk Factors
Internal medicine
Diabetes mellitus
Prevalence
medicine
Humans
Longitudinal Studies
Depression (differential diagnoses)
Angiology
Sweden
Depression
business.industry
Non-cardiovascular morbidity
Middle Aged
Prognosis
medicine.disease
Mental health
Cardiovascular diseases
lcsh:RC666-701
Female
Morbidity
Cardiology and Cardiovascular Medicine
business
Research Article
Subjects
Details
- ISSN :
- 14712261
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- BMC Cardiovascular Disorders
- Accession number :
- edsair.doi.dedup.....e743b568453d192185d5c079bbf2185c