Hepatocyte necrosis on liver allograft biopsy: Normothermic machine perfusion is the ideal platform for using these grafts in high-risk recipients

Hepatocyte necrosis is an undesired finding on liver allograft biopsy and donor transaminases are considered surrogate markers for donor liver allograft quality. Mild to moderate elevation of donor transaminases are not a contraindication to transplantation, however severe elevation often denotes ischaemic hepatocyte necrosis and these grafts are seldom considered for transplantation.