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Accelerated corneal graft rejection in baby rats
- Source :
- British Journal of Ophthalmology. 94:1062-1066
- Publication Year :
- 2009
- Publisher :
- BMJ, 2009.
-
Abstract
- Penetrating keratoplasty in infants has a very poor outcome compared to adults. It is of intrinsic interest to gain insight into the still unknown immunological mechanisms of graft failure because any form of uncorrected corneal opacity leads to amblyopia.Allogeneic keratoplasty was performed between Lewis and Fisher rats. The recipients' ages were 10 and 3 weeks, respectively. All experiments were controlled syngeneically. Survival rates were calculated and cellular infiltrates analysed histologically.Median graft survival times were 15 days in old recipients and 9 days in young recipients (p0.01). There were fewer infiltrating cells in the younger rats than in the older ones on the day of rejection. Despite the fact that T cells dominated there were significantly more NK cells in young recipients at all time points after transplantation when compared to old recipients.An animal model has been established that shows similar rejection kinetics as in children, that is corneal graft failure occurs sooner in young rats. Already little infiltration was sufficient to reject a corneal allograft. The dominance of infiltrating NK cells and the vigorous rejection process suggest an involvement of the innate immune system in this process.
- Subjects :
- CD4-Positive T-Lymphocytes
Graft Rejection
medicine.medical_specialty
Neurology
Inflammation
Adaptive Immunity
CD8-Positive T-Lymphocytes
Cellular and Molecular Neuroscience
Transplantation Immunology
Immunity
Cornea
medicine
Animals
Postoperative Period
Corneal graft rejection
Innate immune system
business.industry
Corneal opacity
Age Factors
Acquired immune system
Immunity, Innate
Rats, Inbred F344
Sensory Systems
Rats
Surgery
Killer Cells, Natural
Disease Models, Animal
Ophthalmology
medicine.anatomical_structure
Rats, Inbred Lew
Female
medicine.symptom
business
Keratoplasty, Penetrating
Subjects
Details
- ISSN :
- 00071161
- Volume :
- 94
- Database :
- OpenAIRE
- Journal :
- British Journal of Ophthalmology
- Accession number :
- edsair.doi.dedup.....e7302b84827069ff9c6cdc1d2c07a2db