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Sero-prevalence of Hepatitis B and C viral co-infections among HIV-1 infected ART-naïve individuals in Kumasi, Ghana
- Source :
- PLoS ONE, Vol 14, Iss 4, p e0215377 (2019)
- Publication Year :
- 2018
-
Abstract
- BackgroundThe study assessed the hepatitis B virus (HBV) and hepatitis C virus (HCV) co-infection paradigm among the human immunodeficiency virus (HIV) infected patients attending a tertiary hospital in Ghana. Also, the immunological and virological characterisation of these viruses, prior to antiretroviral therapy (ART) initiation was investigated.MethodA total of 400 HIV infected (HIV type-1) treatment naïve subjects ≥18 years were enrolled and tested for HBsAg and anti-HCV. Hepatitis B virus serological profile was performed on samples that were HBV positive. CD4+ T-cell count and HIV-1 RNA viral loads were determined using BD FacsCalibur analyzer (USA) and COBAS AmpliPrep/COBAS TaqMan Analyzer (USA) respectively.ResultsThe overall prevalence of HBV/HCV co-infection among the HIV-1 patients was 18.0%. The prevalence of HIV-HBV and HIV-HCV co-infections were 12.5% and 5.5% respectively. The prevalence of active viral hepatitis (HBeAg-positive) among HIV-HBV co-infected patients was 40%. None of the patients had anti-HBc IgM. HIV-HBV co-infection was associated with lower CD4+ T-cell count as well as higher HIV-1 viral load compared to both HIV mono- infection and HIV-HCV co- infection (pConclusionThe present study highlights the predominance of HBV exposure among the HIV infected patients in Ghana. HBV coinfection was associated with severe immunosuppression and higher HIV-1 viral load.
- Subjects :
- 0301 basic medicine
Adult
Male
HBsAg
Adolescent
Science
Hepatitis C virus
030106 microbiology
HIV Infections
medicine.disease_cause
Ghana
03 medical and health sciences
Young Adult
0302 clinical medicine
Seroepidemiologic Studies
Antiretroviral Therapy, Highly Active
medicine
Prevalence
Humans
030212 general & internal medicine
Hepatitis B virus
Multidisciplinary
business.industry
Coinfection
virus diseases
Hepatitis B
Middle Aged
Viral Load
medicine.disease
Virology
Hepatitis C
digestive system diseases
CD4 Lymphocyte Count
HBeAg
HIV-1
Medicine
Female
Viral hepatitis
business
Viral load
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 14
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- PloS one
- Accession number :
- edsair.doi.dedup.....e72bcd40d8ee5924946abd1c7889a4bf