Back to Search
Start Over
Fabrication of UV responsive micelles-containing multilayers and their influence on cell adhesion
- Source :
- Science China Chemistry. 61:54-63
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- Multilayers incorporated with stimuli-responsive substances by means of layer-by-layer (LbL) self-assembly are much attractive due to the advantages of stimuli-responsiveness and potential applications in different fields. In this study, pyrenemethyl acrylate (PA) was synthesized, and was copolymerized with acrylic acid (AA) to obtain the amphiphilic and photodegradable P(PA-co-AA) polymers with a PA:AA molar ratio of 1.3:3, and an average molecular weight of 6.9 kDa and polydispersity index of 1.04. They formed micelles spontaneously when dispersed in aqueous solution with a size of 27.5 nm in a dry state and 136.6 nm in a wet state. The micelles were readily decomposed to form aggregates as a result of the cleavage of the pyrenemethyl ester bonds under UV-irradiation. UV-responsive micelles-containing multilayers were prepared by LbL self-assembly of the UV-responsive micelles and polyallylamine hydrochloride (PAH). UV-irradiation of the multilayers resulted in the decomposition of micelles, leading to larger surface roughness, and enhanced swelling ratio and wettability of the multilayers. In vitro culture of A549 and HepG2 cells showed significantly better adhesion at 4 h on the UV-illuminated multilayers, whereas the cell proliferation was not affected until 5 d. Fil: Zhang, Haolan. Zhejiang University; China Fil: Wang, Danyu. Zhejiang University; China Fil: Lin, Xue. Zhejiang University; China Fil: Politakos, Nikolaos. Centro de Investigación Cooperativa en Biomateriales; España Fil: Tuninetti, Jimena Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Centro de Investigación Cooperativa en Biomateriales; España Fil: Moya, Sergio Enrique. Centro de Investigación Cooperativa en Biomateriales; España Fil: Gao, Changyou. Zhejiang University; China
- Subjects :
- Físico-Química, Ciencia de los Polímeros, Electroquímica
Dispersity
02 engineering and technology
010402 general chemistry
01 natural sciences
Micelle
chemistry.chemical_compound
MULTILAYERS
PHOTO-RESPONSIVE
BIOMATERIALS
Acrylic acid
chemistry.chemical_classification
Acrylate
Aqueous solution
CELL ADHESION
SURFACES
Ciencias Químicas
General Chemistry
Polymer
Adhesion
021001 nanoscience & nanotechnology
0104 chemical sciences
chemistry
Chemical engineering
0210 nano-technology
Polyallylamine hydrochloride
CIENCIAS NATURALES Y EXACTAS
Subjects
Details
- ISSN :
- 18691870 and 16747291
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- Science China Chemistry
- Accession number :
- edsair.doi.dedup.....e718b368588ffc5e15719ce02cf76c14
- Full Text :
- https://doi.org/10.1007/s11426-017-9143-y