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Fabrication of UV responsive micelles-containing multilayers and their influence on cell adhesion

Authors :
Haolan Zhang
Sergio Moya
Danyu Wang
Xue Lin
Jimena Soledad Tuninetti
Nikolaos Politakos
Changyou Gao
Source :
Science China Chemistry. 61:54-63
Publication Year :
2017
Publisher :
Springer Science and Business Media LLC, 2017.

Abstract

Multilayers incorporated with stimuli-responsive substances by means of layer-by-layer (LbL) self-assembly are much attractive due to the advantages of stimuli-responsiveness and potential applications in different fields. In this study, pyrenemethyl acrylate (PA) was synthesized, and was copolymerized with acrylic acid (AA) to obtain the amphiphilic and photodegradable P(PA-co-AA) polymers with a PA:AA molar ratio of 1.3:3, and an average molecular weight of 6.9 kDa and polydispersity index of 1.04. They formed micelles spontaneously when dispersed in aqueous solution with a size of 27.5 nm in a dry state and 136.6 nm in a wet state. The micelles were readily decomposed to form aggregates as a result of the cleavage of the pyrenemethyl ester bonds under UV-irradiation. UV-responsive micelles-containing multilayers were prepared by LbL self-assembly of the UV-responsive micelles and polyallylamine hydrochloride (PAH). UV-irradiation of the multilayers resulted in the decomposition of micelles, leading to larger surface roughness, and enhanced swelling ratio and wettability of the multilayers. In vitro culture of A549 and HepG2 cells showed significantly better adhesion at 4 h on the UV-illuminated multilayers, whereas the cell proliferation was not affected until 5 d. Fil: Zhang, Haolan. Zhejiang University; China Fil: Wang, Danyu. Zhejiang University; China Fil: Lin, Xue. Zhejiang University; China Fil: Politakos, Nikolaos. Centro de Investigación Cooperativa en Biomateriales; España Fil: Tuninetti, Jimena Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Centro de Investigación Cooperativa en Biomateriales; España Fil: Moya, Sergio Enrique. Centro de Investigación Cooperativa en Biomateriales; España Fil: Gao, Changyou. Zhejiang University; China

Details

ISSN :
18691870 and 16747291
Volume :
61
Database :
OpenAIRE
Journal :
Science China Chemistry
Accession number :
edsair.doi.dedup.....e718b368588ffc5e15719ce02cf76c14
Full Text :
https://doi.org/10.1007/s11426-017-9143-y