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Structural requirements of anthocyanins in relation to inhibition of endothelial injury induced by oxidized low-density lipoprotein and correlation with radical scavenging activity
- Source :
- FEBS letters. 584(3)
- Publication Year :
- 2009
-
Abstract
- Anthocyanins may play an important role in atherosclerosis prevention. However, the structure–function relationships are not well understood. The objective of this study was to compare the inhibitory effect of 21 anthocyanins against oxidized low-density lipoprotein-induced endothelial injury to understand the relationship between anthocyanin chemical structure and the endothelial protective properties, measured as cell viability, MDA production and NO release. Additionally, the intracellular anti-radical activity of the selected anthocyanins was investigated to identify the correlation with endothelial protection. Our results provide evidence that the number of –OH in total or in B-ring, 3′,4′-ortho-dihydroxyl and 3-hydroxyl are the main structural requirements of anthocyanins in suppressing oxidative stress-induced endothelial injury and such inhibitory effect was significantly correlated with the intracellular radical scavenging activity.
- Subjects :
- Anthocyanin
Endothelium
Cell Survival
Biophysics
Structure–activity relationship
medicine.disease_cause
Nitric Oxide
Biochemistry
Cell Line
Anthocyanins
chemistry.chemical_compound
Structure-Activity Relationship
Endothelial cell
Structural Biology
Malondialdehyde
Genetics
medicine
Humans
Oxidized low-density lipoprotein
Viability assay
Molecular Biology
chemistry.chemical_classification
Reactive oxygen species
food and beverages
Endothelial Cells
Cell Biology
Free Radical Scavengers
Atherosclerosis
Endothelial stem cell
Lipoproteins, LDL
medicine.anatomical_structure
chemistry
Low-density lipoprotein
Antiradical activity
Oxidative stress
Intracellular
Subjects
Details
- ISSN :
- 18733468
- Volume :
- 584
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- FEBS letters
- Accession number :
- edsair.doi.dedup.....e714127472e0328a977136e89f4bb705