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Dynamics of morphofunctional changes in immune organs of BALB/c mice with experimental hepatitis
- Source :
- Bulletin of experimental biology and medicine. 141(4)
- Publication Year :
- 2006
-
Abstract
- The time course of morphofunctional changes in the liver, thymus, and spleen was observed in BALB/c mice with Con A-induced experimental hepatitis. The progress of alterative changes in the liver was paralleled by intensification of accidental involution of the thymus. On day 1 of hepatitis development high proliferative and cytostatic activity of splenocytes was paralleled by hemorrhagic necroses and depletion of the peri-arteriolar lymphoid sheaths in the spleen (T-zones), presumably due to migration of activated lymphocytes to the liver and barrier tissues. Later normalization of lymphocyte proliferative activity was paralleled by recovery and hyperplasia of the splenic T-cell zones.
- Subjects :
- Male
medicine.medical_specialty
Pathology
Lymphocyte
Spleen
Thymus Gland
Lymphocyte Activation
General Biochemistry, Genetics and Molecular Biology
BALB/c
Hepatitis
Mice
Necrosis
Immune system
Internal medicine
medicine
Splenocyte
Animals
Involution (medicine)
Lymphocytes
Cell Proliferation
Mice, Inbred BALB C
biology
General Medicine
biology.organism_classification
medicine.disease
Disease Models, Animal
medicine.anatomical_structure
Endocrinology
Liver
Hepatocytes
Periarteriolar lymphoid sheaths
Subjects
Details
- ISSN :
- 00074888
- Volume :
- 141
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Bulletin of experimental biology and medicine
- Accession number :
- edsair.doi.dedup.....e6fd2c3e60642f8ade84053405f9c658