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Dynamics of morphofunctional changes in immune organs of BALB/c mice with experimental hepatitis

Authors :
Bogdanova Im
S. S. Obernikhin
M. N. Boltovskaya
O. V. Makarova
V. V. Malaitsev
Source :
Bulletin of experimental biology and medicine. 141(4)
Publication Year :
2006

Abstract

The time course of morphofunctional changes in the liver, thymus, and spleen was observed in BALB/c mice with Con A-induced experimental hepatitis. The progress of alterative changes in the liver was paralleled by intensification of accidental involution of the thymus. On day 1 of hepatitis development high proliferative and cytostatic activity of splenocytes was paralleled by hemorrhagic necroses and depletion of the peri-arteriolar lymphoid sheaths in the spleen (T-zones), presumably due to migration of activated lymphocytes to the liver and barrier tissues. Later normalization of lymphocyte proliferative activity was paralleled by recovery and hyperplasia of the splenic T-cell zones.

Details

ISSN :
00074888
Volume :
141
Issue :
4
Database :
OpenAIRE
Journal :
Bulletin of experimental biology and medicine
Accession number :
edsair.doi.dedup.....e6fd2c3e60642f8ade84053405f9c658