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Platelet volume heterogeneity in acute thrombocytopenia
- Source :
- Clinical physics and physiological measurement : an official journal of the Hospital Physicists' Association, Deutsche Gesellschaft fur Medizinische Physik and the European Federation of Organisations for Medical Physics. 7(3)
- Publication Year :
- 1986
-
Abstract
- Platelet volume and count were measured by aperture impedance techniques in rats during acute thrombocytopenia 2, 6, 12 and 24 h and 3, 6, 9 and 11 days after a single injection of anti-platelet serum (APS). Platelet volume heterogeneity was quantified by four statistical parameters: the measure of central tendency, dispersion, asymmetry and convexity. None of the volume distributions, including the controls, was log Gaussian. Mean platelet volume increased for the first 6 h post APS and then started to decrease although the platelet count had not started to rise. There was an initial increase, followed by a smooth decrease to control values, in the coefficient of variation (suggesting an initial increased dispersion about the mean platelet volume) with concomitant decreases in asymmetry and convexity. In contrast the age of the platelets immediately after the APS injection must have a decreased dispersion about the mean age compared with control values. These facts are used to show that young platelets are not synonymous with large platelets even under the stress of acute thrombocytopenia and support the concept that thrombopoiesis is the dominant factor in determining platelet volume heterogeneity.
- Subjects :
- Blood Platelets
medicine.medical_specialty
Blood Volume
Time Factors
business.industry
Platelet Count
Coefficient of variation
Immune Sera
Biophysics
Large Platelets
Single injection
Thrombocytopenia
Rats
Volume (thermodynamics)
Internal medicine
Concomitant
Immunology
Cardiology
Medicine
Animals
Platelet
Thrombopoiesis
Mean platelet volume
business
Subjects
Details
- ISSN :
- 01430815
- Volume :
- 7
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Clinical physics and physiological measurement : an official journal of the Hospital Physicists' Association, Deutsche Gesellschaft fur Medizinische Physik and the European Federation of Organisations for Medical Physics
- Accession number :
- edsair.doi.dedup.....e6fae59ae95f95f0d0a040d17f143683