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A systematic review of the outcomes reported in trials of medication review in older patients: the need for a core outcome set
- Source :
- British Journal of Clinical Pharmacology
- Publication Year :
- 2016
-
Abstract
- © 2016 The British Pharmacological Society Aim: Medication review has been advocated as one of the measures to tackle the challenge of polypharmacy in older patients, yet there is no consensus on how best to evaluate its efficacy. This study aimed to assess outcome reporting in trials of medication review in older patients. Methods: Randomized controlled trials (RCTs), prospective studies and RCT protocols involving medication review performed in patients aged 65 years or older in any setting of care were identified from: (1) a recent systematic review; (2) RCT registries of ongoing studies; (3) the Cochrane library. The type, definition, and frequency of all outcomes reported were extracted independently by two researchers. Results: Forty-seven RCTs or prospective published studies and 32 RCT protocols were identified. A total of 327 distinct outcomes were identified in the 47 published studies. Only one fifth (21%) of the studies evaluated the impact of medication reviews on adverse events such as drug reactions or drug-related hospital admissions. Most of the outcomes were related to medication use (n = 114, 35%) and healthcare use (n = 74, 23%). Very few outcomes were patient-related (n = 24, 7%). A total of 248 distinct outcomes were identified in the 32 RCT protocols. Overall, the number of outcomes and the number and type of health domains covered by the outcomes varied largely. Conclusion: Outcome reporting from RCTs concerning medication review in older patients is heterogeneous. This review highlights the need for a standardized core outcome set for medication review in older patients, to improve outcome reporting and evidence synthesis.
- Subjects :
- Research design
medicine.medical_specialty
Drug-Related Side Effects and Adverse Reactions
Systematic Reviews
Medication Therapy Management
Alternative medicine
Cochrane Library
030226 pharmacology & pharmacy
law.invention
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
law
Medication therapy management
Outcome Assessment, Health Care
medicine
Humans
Pharmacology (medical)
030212 general & internal medicine
Pharmacology & Pharmacy
Adverse effect
Intensive care medicine
Prospective cohort study
Aged
Randomized Controlled Trials as Topic
Pharmacology
Polypharmacy
business.industry
3. Good health
Research Design
Physical therapy
business
Subjects
Details
- ISSN :
- 13652125
- Volume :
- 83
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- British journal of clinical pharmacology
- Accession number :
- edsair.doi.dedup.....e6f9b7241507a2632158d444d61f66cf