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Telomeres and DNA damage checkpoints
- Source :
- Biochimie. 87:613-624
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- In all eukaryotic organisms, interruptions in duplex DNA molecules elicit a DNA damage response, which includes activation of DNA repair machineries and surveillance mechanisms, known as DNA damage checkpoints. Telomeres and double-strand breaks (DSBs) share the common feature of being physical ends of chromosomes. However, unlike DSBs, telomeres do not activate the DNA damage checkpoints and are usually protected from end-to-end fusions and other processing events that normally promote repair of DNA breaks. This indicates that they are shielded from being recognized and processed as DSBs. On the other hand, chromosome ends resemble damaged DNA, as several factors required for DNA repair and checkpoint networks play important roles in telomere length maintenance. Due to the critical role of both DNA damage checkpoints and telomere homeostasis in maintaining genetic stability and in counteracting cancer development, the knowledge of their interconnections is essential for our understanding of these key cellular controls.
- Subjects :
- DNA Replication
DNA re-replication
DNA Repair
DNA repair
DNA damage
BIO/18 - GENETICA
Biology
Biochemistry
Genomic Instability
chemistry.chemical_compound
Telomere Homeostasis
Humans
Mec1
CHEK1
Telomerase
Genetics
Checkpoint
Tel1
General Medicine
Telomere
G2-M DNA damage checkpoint
chemistry
DNA mismatch repair
biological phenomena, cell phenomena, and immunity
DNA
DNA Damage
Subjects
Details
- ISSN :
- 03009084
- Volume :
- 87
- Database :
- OpenAIRE
- Journal :
- Biochimie
- Accession number :
- edsair.doi.dedup.....e6f5c483cba904607ef7f232f5af265c